Schwartz T M, Turner J G, Brooks B R
Neurosci Lett. 1986 Nov 11;71(2):209-12. doi: 10.1016/0304-3940(86)90560-4.
Thyrotropin-releasing hormone (TRH) metabolism in NIH:N mouse cerebral cortex and spinal cord was studied with high pressure liquid chromatography. Degradation of added TRH was significantly (P less than 0.001) slower in the spinal cord (2.19 +/- 0.46%/min) than in the cerebral cortex (7.54 +/- 0.31%/min). Bacitracin, a non-competitive inhibitor of TRH deamidase, inhibited TRH degradation by 61.3 +/- 3.7% in the spinal cord but only by 35.9 +/- 1.0% in the cerebral cortex (P less than 0.001). Catabolism of TRH in the mouse spinal cord proceeds at a slower rate and predominantly via the TRH deamidase pathway.
采用高压液相色谱法研究了NIH:N小鼠大脑皮层和脊髓中促甲状腺激素释放激素（TRH）的代谢情况。添加的TRH在脊髓中的降解速度（2.19±0.46%/分钟）明显（P<0.001）慢于大脑皮层（7.54±0.31%/分钟）。杆菌肽是TRH脱氨酶的非竞争性抑制剂，在脊髓中可抑制TRH降解61.3±3.7%，而在大脑皮层中仅抑制35.9±1.0%（P<0.001）。小鼠脊髓中TRH的分解代谢速度较慢，且主要通过TRH脱氨酶途径进行。
