Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University., Beijing, (100730), China.
Sci Rep. 2019 Apr 11;9(1):5903. doi: 10.1038/s41598-019-42264-0.
Infection is a fatal complication in cancer patients that sometimes is not distinguished from tumour progression. We compared the diagnostic value of procalcitonin (PCT), C-reactive protein (CRP) and lactate dehydrogenase (LDH) in paediatric malignant solid tumour concurrent with infection and tumour progression. The 152 children enrolled were divided into infection and control groups. Each group was divided further into stable and progression groups. An intergroup comparison was made in terms of serum PCT, CRP and LDH in all children. PCT, CRP and LDH levels were significantly higher in the infection than in the control groups (P < 0.05). Among the controls, PCT, CRP and LDH levels were significantly higher in the progression than in the stable groups (P < 0.05). In diagnosing infection, the sensitivity and specificity of PCT and CRP at the cutoff values of 0.296 ng/mL and 28.13 mg/L were relatively better than those at 0.5 ng/mL and 10 mg/L, respectively. LDH had the highest correlation with tumour progression, whereas PCT had the lowest (LDH, r = 0.684; CRP, r = 0.570; PCT, r = 0.322). Thus, PCT has the highest value in diagnosing infection and is less susceptible to tumour progression than CRP. LDH has obvious advantages in judging tumour progression.
感染是癌症患者的致命并发症，有时与肿瘤进展无法区分。我们比较了降钙素原 (PCT)、C 反应蛋白 (CRP) 和乳酸脱氢酶 (LDH) 在小儿恶性实体瘤并发感染和肿瘤进展中的诊断价值。纳入的 152 名儿童分为感染组和对照组。每组进一步分为稳定组和进展组。比较了所有儿童血清 PCT、CRP 和 LDH 的组间差异。感染组 PCT、CRP 和 LDH 水平明显高于对照组（P<0.05）。在对照组中，进展组 PCT、CRP 和 LDH 水平明显高于稳定组（P<0.05）。在诊断感染方面，PCT 和 CRP 在截断值为 0.296ng/mL 和 28.13mg/L 时的敏感性和特异性优于 0.5ng/mL 和 10mg/L 时。LDH 与肿瘤进展的相关性最高，而 PCT 最低（LDH，r=0.684；CRP，r=0.570；PCT，r=0.322）。因此，PCT 在诊断感染方面具有最高的价值，并且比 CRP 不易受肿瘤进展的影响。LDH 在判断肿瘤进展方面具有明显优势。
