Otani Shunsuke, Chihade Deena B, Coopersmith Craig M
Department of Surgery and Emory Critical Care Center Emory University School of Medicine Atlanta Georgia.
Department of Emergency and Critical Care Medicine Chiba University Graduate School of Medicine Chiba Japan.
Acute Med Surg. 2018 Dec 27;6(2):91-94. doi: 10.1002/ams2.383. eCollection 2019 Apr.
The number of microbes living within the intestinal lumen is similar to the number of all cells of human origin in the host. Although historically little attention has been paid to the massive microbial community residing inside each of us, the last few years have witnessed an explosion of information related to the role of the microbiome in the maintenance of health and in the pathogenesis of disease. Here, we review data suggesting that the microbiome is converted into a pathobiome in critical illness and potential strategies for targeting the microbiome for therapeutic gain in the intensive care unit.
生活在肠腔内的微生物数量与宿主中所有人类源细胞的数量相似。尽管从历史上看，我们对寄居于每个人体内的庞大微生物群落关注甚少，但在过去几年中，与微生物组在维持健康和疾病发病机制中的作用相关的信息呈爆炸式增长。在此，我们综述相关数据，这些数据表明在危重病中微生物组会转变为病理微生物组，以及在重症监护病房针对微生物组以获得治疗益处的潜在策略。
