Parastarfeizabadi Mahboubeh, Kouzani Abbas Z, Beckinghausen Jaclyn, Lin Tao, Sillitoe Roy V
School of Engineering, Deakin University, Geelong, VIC 3216, Australia.
Department of Pathology and Immunology, Department of Neuroscience, and Jan and Dan Duncan Neurological Research Institute of Texas Children's Hospital, 1250 Moursund Street, Suite 1325, Houston Texas 77030, USA.
IEEE Access. 2018;7:230-244. doi: 10.1109/ACCESS.2018.2885336. Epub 2018 Dec 7.
Most of the current closed-loop DBS devices use a single biomarker in their feedback loop which may limit their performance and applications. This paper presents design, fabrication, and validation of a programmable multi-biomarker neural sensor which can be integrated into closed-loop DBS devices. The device is capable of sensing a combination of low-frequency (7-45 Hz), and high-frequency (200-1000 Hz) neural signals. The signals can be amplified with a digitally programmable gain within the range 50-100 dB. The neural signals can be stored into a local memory for processing and validation. The sensing and storage functions are implemented via a combination of analog and digital circuits involving preamplifiers, filters, programmable post-amplifiers, microcontroller, digital potentiometer, and flash memory. The device is fabricated, and its performance is validated through: (i) bench tests using sinusoidal and pre-recorded neural signals, (ii) in-vitro tests using pre-recorded neural signals in saline solution, and (iii) in-vivo tests by recording neural signals from freely-moving laboratory mice. The animals were implanted with a PlasticsOne electrode, and recording was conducted after recovery from the electrode implantation surgery. The experimental results are presented and discussed confirming the successful operation of the device. The size and weight of the device enable tetherless back-mountable use in pre-clinical trials.
当前大多数闭环深部脑刺激（DBS）设备在其反馈回路中使用单一生物标志物，这可能会限制其性能和应用。本文介绍了一种可编程多生物标志物神经传感器的设计、制造和验证，该传感器可集成到闭环DBS设备中。该设备能够感应低频（7 - 45赫兹）和高频（200 - 1000赫兹）神经信号的组合。这些信号可以通过50 - 100分贝范围内的数字可编程增益进行放大。神经信号可以存储到本地存储器中进行处理和验证。传感和存储功能通过模拟和数字电路的组合来实现，这些电路包括前置放大器、滤波器、可编程后置放大器、微控制器、数字电位器和闪存。该设备已制造完成，并通过以下方式验证其性能：（i）使用正弦波和预先录制的神经信号进行台架测试，（ii）在盐溶液中使用预先录制的神经信号进行体外测试，以及（iii）通过记录自由活动的实验小鼠的神经信号进行体内测试。给动物植入了PlasticsOne电极，并在电极植入手术恢复后进行记录。展示并讨论了实验结果，证实了该设备的成功运行。该设备的尺寸和重量使其能够在临床前试验中进行无系绳的背部安装使用。
