Parastarfeizabadi Mahboubeh, Kouzani Abbas Z
School of EngineeringDeakin UniversityGeelongVIC3216Australia.
IEEE J Transl Eng Health Med. 2019 Aug 30;7:2000308. doi: 10.1109/JTEHM.2019.2937776. eCollection 2019.
In this paper, a dual-biomarker-based neural sensing and conditioning device is proposed for closing the feedback loop in deep brain stimulation devices. The device explores both local field potentials (LFPs) and action potentials (APs) as measured biomarkers. It includes two channels, each having four main parts: (1) a pre-amplifier with built-in low-pass filter, (2) a ground shifting circuit, (3) an amplifier with low-pass function, and (4) a high-pass filter. The design specifications include miniature-size, light-weight, and 100 dB gain in the LFP and AP channels. This device has been validated through bench and in-vitro tests. The bench tests have been performed using different sinusoidal signals and pre-recorded neural signals. The in-vitro tests have been conducted in the saline solution that mimics the brain environment. The total weight of the device including a 3 V coin battery, and battery holder is 1.2 g. The diameter of the device is 11.2 mm. The device can be used to concurrently sense LFPs and APs for closing the feedback loop in closed-loop deep brain stimulation systems. It provides a tetherless head-mountable platform suitable for pre-clinical trials.
本文提出了一种基于双生物标志物的神经传感与调节装置，用于闭合深部脑刺激装置中的反馈回路。该装置将局部场电位（LFP）和动作电位（AP）作为测量的生物标志物进行探索。它包括两个通道，每个通道有四个主要部分：（1）带有内置低通滤波器的前置放大器，（2）接地移位电路，（3）具有低通功能的放大器，以及（4）高通滤波器。设计规格包括微型尺寸、轻量化，以及LFP和AP通道100 dB的增益。该装置已通过台架测试和体外测试验证。台架测试使用了不同的正弦信号和预先记录的神经信号。体外测试是在模拟脑环境的盐溶液中进行的。该装置包括一个3 V硬币电池和电池座，总重量为1.2 g。装置直径为11.2 mm。该装置可用于同时感测LFP和AP，以闭合闭环深部脑刺激系统中的反馈回路。它提供了一个适用于临床前试验的无束缚头戴式平台。
