Skill Nicholas, Maluccio Mary
Indiana University School of Medicine, Indianapolis, IN, USA.
Transl Gastroenterol Hepatol. 2019 Feb 25;4:14. doi: 10.21037/tgh.2019.01.13. eCollection 2019.
Gastric cancer is the third leading cause of cancer mortality worldwide. Survival is linked to stage at diagnosis and tolerance to surgery and adjuvant therapy. The emergence of sophisticated methods to identify patients at high risk for the development of gastric cancer has given us an opportunity to eliminate a lethal disease in an identifiable patient population. Guidelines and recommendations have been established and prophylactic total gastrectomy is considered the most effective treatment. However, this requires substantial physical and emotional investment. It is imperative that patients and families are supported by genetic counseling, ongoing surveillance, and survivorship studies.
胃癌是全球癌症死亡的第三大主要原因。生存率与诊断时的分期以及对手术和辅助治疗的耐受性相关。识别胃癌高危患者的精密方法的出现，为我们提供了一个在可识别的患者群体中消除这种致命疾病的机会。已经制定了指南和建议，预防性全胃切除术被认为是最有效的治疗方法。然而，这需要大量的身体和情感投入。患者和家庭必须得到遗传咨询、持续监测和生存研究的支持。
