Schäfer K, Iwainsky H, Schilling W
Pharmazie. 1986 Aug;41(8):591-3.
A narrow therapeutic index, considerable interpatients variability of clearance and biotransformation, rapid alterations of pharmacokinetics point out theophylline to a problem-drug. An effective long-term treatment with this drug is only possible with retard-preparations. For a certain therapy a drug monitoring-controlling the theophylline-concentration in the serum--is necessary, in what extend and under which conditions is discussed in detail.
治疗指数狭窄、患者间清除率和生物转化的显著差异以及药代动力学的快速变化表明茶碱是一种问题药物。只有使用缓释制剂才能对该药物进行有效的长期治疗。对于特定的治疗，需要进行药物监测——控制血清中的茶碱浓度——详细讨论了其程度和条件。
