Utama I, Kreukniet J, Fokkens J, Serra R
Int J Clin Pharmacol Ther Toxicol. 1983 Jun;21(6):292-6.
Six normals and six patients with chronic obstructive lung disease were treated with a short- and long-acting theophylline (Theolair and Theolair retard). During treatment the lung function data of the patients showed an improvement on day 1, but no further improvement on days 4 and 7, despite the higher theophylline plasma concentration on these last days. There was no close correlation between the improvement of lung function and the theophylline plasma concentration, nor was there any difference between Theolair and Theolair retard as regards improvement of lung function. Side effects were negligible, and the theophylline plasma concentration was rather low. It seems advisable to use a higher dosage of the theophyllines and perhaps it is even better to combine them with other bronchodilators.
六名健康受试者和六名慢性阻塞性肺疾病患者接受了短效和长效茶碱（茶喘平及茶喘平缓释片）治疗。治疗期间，患者的肺功能数据在第1天有所改善，但在第4天和第7天没有进一步改善，尽管这最后几天茶碱的血浆浓度较高。肺功能的改善与茶碱血浆浓度之间没有密切相关性，茶喘平与茶喘平缓释片在肺功能改善方面也没有差异。副作用可忽略不计，且茶碱血浆浓度相当低。似乎建议使用更高剂量的茶碱，或许将它们与其他支气管扩张剂联合使用会更好。
