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RO 15-1788 does not influence postpartum aggression in lactating female rats.

作者信息

Mos J, Olivier B

出版信息

Psychopharmacology (Berl). 1986;90(2):278-80. doi: 10.1007/BF00181259.

DOI:10.1007/BF00181259
PMID:3097713
Abstract

Recently, Hansen et al. (1985) suggested behavioural similarities between lactating rats and non-maternal rats treated with benzodiazepines (BDZ), indicating that lactation may be associated with an increased activity state at the GABA/BDZ receptor complex similar to BDZ treatment. A logical prediction of this hypothesis is that BDZ antagonists should decrease typical maternal behaviours involved, such as aggression. We tested this hypothesis by measuring the behavioural effects of the BDZ antagonist RO 15-1788 (1.25-10 mg/kg IP) on aggressive behaviour of lactating female rats confronted with male intruders. We could not support the hypothesis; no consistent behavioural effects of RO 15-1788 on aggression were found. The implications of this finding for the proposed hypothesis are discussed.

摘要

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本文引用的文献

1
Effects of the benzodiazepine antagonist Ro 15-1788 on social and agonistic behaviour in male albino mice.苯二氮䓬拮抗剂Ro 15 - 1788对雄性白化小鼠社交和攻击行为的影响。
Physiol Behav. 1984 Sep;33(3):401-9. doi: 10.1016/0031-9384(84)90161-6.
2
Multiple sites of action for anxiogenic drugs: behavioural, electrophysiological and biochemical correlations.抗焦虑药物的多个作用位点：行为、电生理及生化相关性
Psychopharmacology (Berl). 1984;83(4):304-15. doi: 10.1007/BF00428536.
3
Benzodiazepine-receptor mediated inhibition of isolation-induced aggression in mice.
GABA(A) receptor signaling in the lateral septum regulates maternal aggression in mice.
外侧隔区中的γ-氨基丁酸A型（GABA(A)）受体信号传导调节小鼠的母性攻击行为。
Behav Neurosci. 2009 Dec;123(6):1169-77. doi: 10.1037/a0017535.
4
Behavioral effects of flumazenil in the social conflict test in mice.氟马西尼在小鼠社会冲突试验中的行为效应。
Psychopharmacology (Berl). 2004 Jan;171(3):259-69. doi: 10.1007/s00213-003-1583-y. Epub 2003 Sep 5.
5
Prevention of the pro-aggressive effects of alcohol in rats and squirrel monkeys by benzodiazepine receptor antagonists.苯二氮䓬受体拮抗剂对大鼠和松鼠猴酒精促攻击作用的预防
Psychopharmacology (Berl). 1993;111(2):144-52. doi: 10.1007/BF02245516.
6
"Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys.“抗焦虑”和“致焦虑”的苯二氮䓬类药物及β-咔啉：对大鼠和松鼠猴攻击行为及社会行为的影响
Psychopharmacology (Berl). 1993;110(4):451-9. doi: 10.1007/BF02244652.
Pharmacol Biochem Behav. 1985 Jul;23(1):17-20. doi: 10.1016/0091-3057(85)90123-6.