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抗焦虑药物的多个作用位点：行为、电生理及生化相关性

Multiple sites of action for anxiogenic drugs: behavioural, electrophysiological and biochemical correlations.

作者信息

Pellow S, File S E

出版信息

Psychopharmacology (Berl). 1984;83(4):304-15. doi: 10.1007/BF00428536.

DOI:10.1007/BF00428536
PMID:6093178
Abstract

This review describes animal models of anxiety that are able to identify an anxiogenic drug effect. Evidence is reviewed for the anxiogenic action of several drugs that act at the GABA-benzodiazepine-chloride ionophore complex in the brain. The effects of their combinations with various other drugs thought to act at the same sites are discussed. The classification of these drugs on the basis of their behavioural profiles is compared with their classification based on biochemical and electrophysiological studies.

摘要

本综述描述了能够识别致焦虑药物效应的焦虑动物模型。综述了几种作用于大脑中γ-氨基丁酸-苯二氮䓬-氯离子载体复合物的药物的致焦虑作用的证据。讨论了它们与其他被认为作用于相同位点的药物联合使用的效果。将这些药物基于行为特征的分类与其基于生化和电生理研究的分类进行了比较。

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