Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea; Division of Brain Korea 21 Program for Biomedicine Science, College of Medicine, Korea University, Seoul, South Korea.
J Clin Virol. 2019 Jun;115:47-52. doi: 10.1016/j.jcv.2019.03.016. Epub 2019 Mar 27.
Influenza C virus has been largely neglected, compared to influenza A orB viruses, and is not routinely tested in clinical practices. However, several studies have indicated that influenza C virus causes severe acute respiratory illness and pneumonia in all ages.
We conducted a study to identify influenza C virus among young children in South Korea.
From October 2013 to September 2016, 973 young children with influenzalike illness (ILI) were enrolled at three university hospitals. We tested nasopharyngeal samples for 16 types of respiratory viruses. Among the tested samples, 564 were positive for one or more respiratory viruses. Except for the samples where 16 types of respiratory viruses were found, 409 negative samples were examined for the presence of influenza C virus, using a matrix gene specific primer set.
Among 409 nasopharyngeal samples, five influenza C viruses were detected. The manifestation of influenza C virus infection in young children was observed acute respiratory illness, such as fever, rhinorrhea, and cough, but no pneumonia or severe respiratory illness. Nucleotide sequencing was conducted and a phylogenetic tree was generated. We found that C/Sao Paulo/387/82-like lineage viruses circulated in South Korea, and the fully sequenced virus (C/Seoul/APD462/2015) was closely related to C/Victoria/2/2012 and C/Tokyo/4/2014 strains.
This study was the first report of influenza C virus detection in South Korea. Although severe illness was not observed in this study, we suggest the necessity for influenza C virus testing in pediatric patients with ILI, considering other reports of severe illnesses caused by influenza C virus infections.
与甲型或乙型流感病毒相比，丙型流感病毒在很大程度上被忽视，并且在临床实践中通常不进行常规检测。然而，有几项研究表明，丙型流感病毒可导致各年龄段的严重急性呼吸道疾病和肺炎。
我们进行了一项研究，以确定韩国的儿童中丙型流感病毒的情况。
2013 年 10 月至 2016 年 9 月，在三家大学医院共招募了 973 名有流感样疾病（ILI）的幼儿。我们检测了鼻咽样本中的 16 种呼吸道病毒。在所测试的样本中，有 564 个样本对一种或多种呼吸道病毒呈阳性。除了发现 16 种呼吸道病毒的样本外，我们还使用基质基因特异性引物组检查了 409 个阴性样本中是否存在丙型流感病毒。
在 409 个鼻咽样本中，检测到了 5 株丙型流感病毒。丙型流感病毒感染幼儿的表现为急性呼吸道疾病，如发热、流涕和咳嗽，但无肺炎或严重呼吸道疾病。进行了核苷酸测序并生成了系统发育树。我们发现，丙型流感病毒/Sao Paulo/387/82 类似株系病毒在韩国传播，而完全测序的病毒（丙型流感病毒/Seoul/APD462/2015）与丙型流感病毒/C/Victoria/2/2012 和丙型流感病毒/C/Tokyo/4/2014 株密切相关。
本研究首次报告了韩国丙型流感病毒的检测情况。尽管本研究中未观察到严重疾病，但鉴于丙型流感病毒感染引起严重疾病的其他报道，我们建议对有 ILI 的儿科患者进行丙型流感病毒检测。
