Lee Han Sol, Noh Ji Yun, Cheong Hee Jin
Asia Pacific Influenza Institute, Korea University College of Medicine, Seoul, Korea.
Division of Infectious Diseases, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Clin Exp Vaccine Res. 2025 Jul;14(3):203-209. doi: 10.7774/cevr.2025.14.e32. Epub 2025 Jul 8.
Influenza C virus (ICV) was discovered in 1947 and detected in humans, with natural infections occurring periodically. However, early studies on ICV were challenging in diagnosis because the virus is difficult to culture. As a result, the disease burden and pathogenicity of ICV have been underestimated. Recent studies using molecular biological techniques such as real-time polymerase chain reaction have provided further insights into prevalence, seasonality, genomic diversity, and evolution. In addition, the possibility of interspecies transmission was suggested based on the high similarity between the nucleotide sequence of ICV confirmed to infect animals and the sequence of ICV isolated from humans. In this review, we summarize current data on the epidemiology and clinical features, viral genome analysis, and animal studies of ICV.
丙型流感病毒（ICV）于1947年被发现，并在人类中被检测到，自然感染会周期性发生。然而，早期对ICV的研究在诊断方面具有挑战性，因为该病毒难以培养。因此，ICV的疾病负担和致病性一直被低估。最近使用实时聚合酶链反应等分子生物学技术的研究，为其流行情况、季节性、基因组多样性和进化提供了进一步的见解。此外，基于已证实感染动物的ICV核苷酸序列与从人类分离的ICV序列高度相似，提示了种间传播的可能性。在本综述中，我们总结了关于ICV的流行病学和临床特征、病毒基因组分析及动物研究的当前数据。
