Institute of Pharmaceutical Technology, Lithuanian University of Health Sciences, A.Mickevičiaus g. 9, LT-44307, Kaunas, Lithuania.
Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, A.Mickevičiaus g. 9, LT-44307, Kaunas, Lithuania.
Molecules. 2019 Apr 11;24(7):1442. doi: 10.3390/molecules24071442.
The increased interest in functional materials of natural origin has resulted in a higher market demand for preservative-free, "clean label", or natural ingredients-based products. The gummy bear food supplements are more acceptable to consumers and have fewer limitations compared to other dosage forms. The aim of our study was to produce natural ingredients-based gummy bear composition, and evaluate the influence of the selected ingredients on the product's textural properties, its acceptance in vivo, and the gummy bear's quality. The optimal base composition was determined using a surface response design: gelatin 4.3 g and agave syrup 6.3 g. The investigated sweeteners did not affect the textural properties ( > 0.05). However, further studies demonstrated that a 100% increase of agave results in up to 27% higher flexibility ( < 0.05). The addition of calcium and cholecalciferol reduced firmness by 59.59 ± 1.45% ( < 0.05). On the other hand, acai berry extract had no significant effect. The presence of calcium resulted in a decreased smell and taste; however, the data indicated that experimental texture analysis is a more accurate technique than in vivo evaluation. The acai berry extract did not improve all of the tested sensory properties. We can conclude that the suggested gummy bear base can be supplemented with various active ingredients and commercialized, though further studies are needed to investigate the other natural sources to mask the unpleasant taste of active ingredients and avoid water loss.
对天然来源的功能材料的兴趣日益浓厚,导致对无防腐剂、“清洁标签”或基于天然成分的产品的市场需求增加。与其他剂型相比, gummy bear 食品补充剂更受消费者接受,限制也更少。我们的研究目的是生产基于天然成分的 gummy bear 配方,并评估所选成分对产品质地特性、体内接受度以及 gummy bear 质量的影响。使用表面响应设计确定了最佳基础配方:明胶 4.3 克和龙舌兰花蜜 6.3 克。研究的甜味剂不会影响质地特性(>0.05)。然而,进一步的研究表明,龙舌兰花蜜增加 100%可使柔韧性提高高达 27%(<0.05)。添加钙和胆钙化醇可使硬度降低 59.59±1.45%(<0.05)。另一方面,acai 莓提取物没有明显效果。钙的存在会降低气味和味道;然而,数据表明,实验性质地分析比体内评估更准确。acai 莓提取物并没有改善所有测试的感官特性。我们可以得出结论,建议的 gummy bear 基础可以补充各种活性成分并商业化,尽管需要进一步研究其他天然来源以掩盖活性成分的不愉快味道并避免水分流失。