Yang Liqun, Li Jianxin, Li Miao, Gu Zhongwei
Key Laboratory of Reproductive Health and Medical Genetics, National Health and Family Planning Commission, Shenyang 110031, China.
Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, Shenyang 110031, China.
Polymers (Basel). 2016 Apr 19;8(4):151. doi: 10.3390/polym8040151.
The degradation of the poly(trimethylene carbonate) (PTMC) and poly(trimethylene carbonate--ε-caprolactone) (P(TMC--CL)) networks cross-linked by 0.01 and 0.02 mol % 2,2'-bis(trimethylene carbonate-5-yl)-butylether (BTB) was carried out in the conditions of hydrolysis and enzymes and subcutaneous implantation . The results showed that the cross-linked PTMC networks exhibited much faster degradation in enzymatic conditions and in a hydrolysis case due to the catalyst effect of enzymes; the weight loss and physical properties of the degraded networks were dependent on the BTB amount. The morphology observation in lipase and illustrated that enzymes played an important role in the surface erosion of cross-linked PTMC. The hydrolytic degradation rate of the cross-linked P(TMC--CL) networks increased with increasing ε-caprolactone (CL) content in composition due to the preferential cleavage of ester bonds. Cross-linking is an effective strategy to lower the degradation rate and enhance the form-stability of PTMC-based materials.
通过0.01和0.02 mol%的2,2'-双(三亚甲基碳酸酯-5-基)-丁基醚(BTB)交联的聚三亚甲基碳酸酯(PTMC)和聚(三亚甲基碳酸酯-ε-己内酯)(P(TMC-CL))网络在水解、酶解和皮下植入条件下进行降解。结果表明，由于酶的催化作用，交联的PTMC网络在酶解条件下和水解情况下表现出更快的降解；降解网络的失重和物理性能取决于BTB的用量。脂肪酶中的形态观察表明，酶在交联PTMC的表面侵蚀中起重要作用。由于酯键的优先断裂，交联的P(TMC-CL)网络的水解降解速率随着组合物中ε-己内酯(CL)含量的增加而增加。交联是降低基于PTMC材料的降解速率并提高其形状稳定性的有效策略。
