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用于疏水性药物运输的聚酯基可生物降解核-多壳层纳米载体

Polyester-Based, Biodegradable Core-Multishell Nanocarriers for the Transport of Hydrophobic Drugs.

作者信息

Walker Karolina A, Stumbé Jean-François, Haag Rainer

机构信息

Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.

Laboratoire de Photochimie et d'Ingénierie Macromoléculaires, Université de Haute Alsace, 3 rue Alfred Werner, 68093 Mulhouse Cedex, France.

出版信息

Polymers (Basel). 2016 May 14;8(5):192. doi: 10.3390/polym8050192.

DOI:10.3390/polym8050192
PMID:30979288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6432435/
Abstract

A water-soluble, core-multishell (CMS) nanocarrier based on a new hyperbranched polyester core building block was synthesized and characterized towards drug transport and degradation of the nanocarrier. The hydrophobic drug dexamethasone was encapsulated and the enzyme-mediated biodegradability was investigated by NMR spectroscopy. The new CMS nanocarrier can transport one molecule of dexamethasone and degrades within five days at a skin temperature of 32 °C to biocompatible fragments.

摘要

基于一种新型超支化聚酯核构建块合成了一种水溶性核-多壳（CMS）纳米载体，并对其进行了药物运输和纳米载体降解方面的表征。将疏水性药物地塞米松进行了包封，并通过核磁共振光谱研究了酶介导的生物降解性。这种新型CMS纳米载体能够运输一分子地塞米松，并在32℃的皮肤温度下于五天内降解为生物相容性片段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/859281727c03/polymers-08-00192-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/c5e77a604d15/polymers-08-00192-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/be186073db31/polymers-08-00192-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/98d7e6d5e862/polymers-08-00192-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/400b7491abf0/polymers-08-00192-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/a10549fb9d96/polymers-08-00192-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/93a31aca1e2a/polymers-08-00192-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/edd06c62034f/polymers-08-00192-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/36cd87e55768/polymers-08-00192-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/9b6b18ed8293/polymers-08-00192-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/bef4b0c2fb25/polymers-08-00192-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/09c6a55af1cc/polymers-08-00192-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/1dfc83a44780/polymers-08-00192-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/995c3c016ac2/polymers-08-00192-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/51cb7ac33215/polymers-08-00192-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/14dcf9d260be/polymers-08-00192-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/47660bf64ccd/polymers-08-00192-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/7c38f531281d/polymers-08-00192-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/c99038edc8c8/polymers-08-00192-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/859281727c03/polymers-08-00192-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/c5e77a604d15/polymers-08-00192-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/be186073db31/polymers-08-00192-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/98d7e6d5e862/polymers-08-00192-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/400b7491abf0/polymers-08-00192-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/a10549fb9d96/polymers-08-00192-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/93a31aca1e2a/polymers-08-00192-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/edd06c62034f/polymers-08-00192-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/36cd87e55768/polymers-08-00192-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/9b6b18ed8293/polymers-08-00192-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/bef4b0c2fb25/polymers-08-00192-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/09c6a55af1cc/polymers-08-00192-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/1dfc83a44780/polymers-08-00192-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/995c3c016ac2/polymers-08-00192-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/51cb7ac33215/polymers-08-00192-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/14dcf9d260be/polymers-08-00192-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/47660bf64ccd/polymers-08-00192-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/7c38f531281d/polymers-08-00192-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/c99038edc8c8/polymers-08-00192-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f120/6432435/859281727c03/polymers-08-00192-g005.jpg

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