Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.
Chem Soc Rev. 2015 Jun 21;44(12):4145-64. doi: 10.1039/c4cs00333k.
Hyperbranched polymers are obtained through one-step polymerization reactions and exhibit properties that are very similar to those of perfect dendrimer analogues. Therefore, hyperbranched polymers are a suitable alternative for perfect dendrimers as building blocks for dendritic nanocarrier systems. With regard to using soluble hyperbranched polymers as carrier systems, their flexible chains are a major benefit as they can adopt and compartment guest molecules. Upon encapsulation, the properties of the host decides the fate of the guest, e.g., solubility, but the host can also shield a guest from the environment and protect it, e.g., from degradation and deactivation. With regard to the advantages of using hyperbranched polymers as nanocarrier systems and their scalable synthesis, we will discuss different types of hyperbranched polymers and their application as nanocarrier systems for drugs, dyes, and other guest molecules.
超支化聚合物是通过一步聚合反应得到的，其性质与完美的树枝状大分子类似。因此，超支化聚合物是完美树枝状大分子作为树枝状纳载体系统构建基块的合适替代品。对于使用可溶性超支化聚合物作为载体系统，其柔性链是一个主要的优势，因为它们可以采用和分隔客体分子。客体分子包封后，主体的性质决定了客体的命运，例如溶解度，但主体也可以将客体与环境隔离并保护它，例如防止降解和失活。关于使用超支化聚合物作为纳载体系统的优势及其可扩展的合成，我们将讨论不同类型的超支化聚合物及其作为药物、染料和其他客体分子的纳载体系统的应用。
