Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.
Biotechnol Adv. 2015 Nov 1;33(6 Pt 3):1327-41. doi: 10.1016/j.biotechadv.2015.03.014. Epub 2015 Apr 11.
Unimolecular micelles are covalently bound molecular architectures and therefore highly stable which makes them particularly attractive for drug delivery. Accordingly, many reports in the literature emphasize the importance of these molecular architectures for nanomedicine. This conceptual review will present some of the recent advances in the application of these dendritic core-shell systems for drug delivery. Unimolecular micelles based on hyperbranched and dendritic cores will be discussed and sorted by the nature of their core and structure.
单分子胶束是通过共价键结合的分子结构，因此非常稳定，这使得它们在药物传递方面特别有吸引力。因此，文献中有许多报道强调了这些分子结构在纳米医学中的重要性。本综述将介绍这些树状核-壳体系在药物传递方面的一些最新进展。将根据核心的性质和结构对基于超支化和树状核心的单分子胶束进行讨论和分类。
