Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Sleep Med. 2020 Feb;66:286-290. doi: 10.1016/j.sleep.2019.02.008. Epub 2019 Feb 22.
Although a few studies suggest an adverse effect of sleep duration variability on cardiovascular risk factor, others did not and this association remains controversial. Moreover, most studies were non-representative of the general population, used different sleep duration variability measures, and relied on self-reported sleep duration. We aimed to assess the association between different, actigraphy-based sleep duration variability measures and cardiovascular risk factors in a population-based sample.
In a middle-aged population-based cohort, 2598 subjects had data on sleep duration variability measured by actigraph over 14 days. Multivariable logistic regressions were performed to assess the relationship between different sleep duration variability measures [ie, night-to-night variability (NNV), range between shortest and longest sleep duration (RSL), range between average weekday and weekend sleep duration (RWW)] and cardiovascular risk factors including obesity, diabetes and hypertension.
Subjects with highest sleep duration variability - measured as NNV, RSL and RWW, were more likely to be obese. These associations robust in most but not all sensitivity analyses, and no associations between sleep duration variability measures and diabetes or hypertension were found.
There is a possible association between high sleep duration variability and obesity, although results were not robust in all sensitivity analyses. Further, no associations between sleep duration variability and other cardiovascular risk factor such as diabetes or hypertension were found.
尽管有一些研究表明睡眠时长变异性对心血管风险因素有不良影响，但其他研究并未发现这种关联，因此该关联仍存在争议。此外，大多数研究都不能代表一般人群，使用了不同的睡眠时长变异性衡量指标，并且依赖于自我报告的睡眠时长。我们旨在评估基于活动记录仪的不同睡眠时长变异性衡量指标与心血管风险因素之间的关联，该研究基于人群样本。
在一项中年人群的基于人群的队列研究中，有 2598 名受试者的睡眠时长变异性数据通过活动记录仪测量了 14 天。多变量逻辑回归用于评估不同的睡眠时长变异性衡量指标[即，夜间到夜间的变异性（NNV）、最短和最长睡眠时间之间的范围（RSL）、平均工作日和周末睡眠时间之间的范围（RWW）]与心血管风险因素（包括肥胖、糖尿病和高血压）之间的关系。
睡眠时长变异性最高的受试者——表现为 NNV、RSL 和 RWW，更有可能肥胖。这些关联在大多数但不是所有敏感性分析中都是稳健的，而在睡眠时长变异性衡量指标与糖尿病或高血压之间没有发现关联。
尽管在所有敏感性分析中，结果并不稳健，但高睡眠时长变异性与肥胖之间可能存在关联。此外，在睡眠时长变异性与其他心血管风险因素（如糖尿病或高血压）之间没有发现关联。
