The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA
J Cell Biol. 2019 May 6;218(5):1434-1435. doi: 10.1083/jcb.201903065. Epub 2019 Apr 12.
How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size.
神经元如何在改变突触形态或功能的条件下稳定其整体突触强度，是神经元内稳态的一个关键问题。在本期杂志中，Goel 等人（2019. https://doi.org/10.1083/jcb.201807165）发现，神经元通过控制活性区物质和活性区大小的输送来稳定突触输出，尽管突触大小、活性区数量或突触后功能受到了破坏。
