Alliluev A P, Kotel'nikova O V, Kuvakina V A, Basnak'ian I A, Valerius I I
Zh Mikrobiol Epidemiol Immunobiol. 1986 Sep(9):7-12.
The complex preparations of group B meningococcal polysaccharide have been found to be capable of inducing primary immune response in mice, while purified group B polysaccharide has proved to be immunologically inert. As revealed in this investigation, the intravenous injection to mice of the optimum doses of the complex preparation of group B polysaccharide leads to the increased number of specific B-antibody-forming cells in their spleens and to a rise in B-antibody titers in their sera; besides, the time course of the process has been studied. Both preparations have been found capable of forming the immunological memory in mice if booster immunization is made with the complex preparation of group B polysaccharide. The immunological inertness of purified group B polysaccharide is attributed, supposedly, to the action of some specific suppressor mechanism. Considering the pronounced antigenic activity of the complex preparation of group B polysaccharide and the insignificant admixture of endotoxin in this preparation, the suitability of its future use as vaccine for the prophylaxis of meningitis caused by group B meningococcus is indicated and the tentative immunization schedules are discussed.
已发现B群脑膜炎球菌多糖的复合制剂能够在小鼠中诱导初次免疫反应，而纯化的B群多糖已被证明在免疫上无活性。如本研究所示，给小鼠静脉注射最佳剂量的B群多糖复合制剂会导致其脾脏中特异性B抗体形成细胞数量增加，血清中B抗体滴度升高；此外，还研究了该过程的时间进程。如果用B群多糖复合制剂进行加强免疫，已发现这两种制剂都能够在小鼠中形成免疫记忆。纯化的B群多糖在免疫上无活性据推测归因于某种特异性抑制机制的作用。考虑到B群多糖复合制剂具有显著的抗原活性且该制剂中内毒素的含量极少，表明其未来用作预防B群脑膜炎球菌引起的脑膜炎疫苗的适用性，并讨论了初步的免疫接种方案。
