用与外膜蛋白复合的B群脑膜炎球菌多糖对小鼠进行疫苗接种后的胸腺依赖性和免疫记忆
Thymic-dependence and immune memory in mice vaccinated with meningococcal polysaccharide group B complexed to outer membrane protein.
作者信息
Moreno C, Esdaile J, Lifely M R
出版信息
Immunology. 1986 Mar;57(3):425-30.
Abstract
Athymic mice were capable of producing IgM antibodies to B polysaccharide of N. meningitidis when immunized with the polysaccharide complexed to outer membrane proteins, whereas no immunogenicity could be demonstrated with the purified polysaccharide. Transfer of T cells to athymic cells demonstrated that the primary anti-B response was truly thymus-independent but the bulk of the secondary response was thymus-dependent. Transfer of T and B cells purified from spleens of immune mice into irradiated recipients showed the presence of memory T cells, but no memory B cells could be found.
摘要
无胸腺小鼠在用与外膜蛋白复合的多糖免疫时，能够产生针对脑膜炎奈瑟菌B多糖的IgM抗体，而纯化的多糖则无免疫原性。将T细胞转移至无胸腺细胞表明，初次抗B反应确实是胸腺非依赖性的，但大部分二次反应是胸腺依赖性的。将从免疫小鼠脾脏中纯化的T细胞和B细胞转移至受辐照的受体，结果显示存在记忆T细胞，但未发现记忆B细胞。
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