Jiang Qin, Xia Yingzi, Barrett Jacob, Mikhailovsky Alexander, Wu Guang, Wang Daqi, Shi Pengfei, Ford Peter C
Department of Chemistry and Biochemistry , University of California, Santa Barbara , Santa Barbara , California 93106 , United States.
School of Chemistry and Chemical Engineering , Jiangsu Ocean University , Lianyungang" 222005 , Jiangsu , People's Republic China.
Inorg Chem. 2019 Aug 19;58(16):11066-11075. doi: 10.1021/acs.inorgchem.9b01581. Epub 2019 Aug 1.
Multiphoton excitation allows one to access high energy excited states and perform valuable tasks in biological systems using tissue penetrating near-infrared (NIR) light. Here, we describe new photoactive manganese tricarbonyl complexes incorporating the ligand 4'-p-N,N-bis(2-hydroxyethyl)amino-benzyl-2,2':6',2″-terpyridine (TPYOH), which can serve as an antenna for two photon NIR excitation. Solutions of Mn(CO)(TPYOH)X (X = Br or CFSO) complexes are very photoactive toward CO release under visible light excitation (405 nm, 451 nm). The same responses were also triggered by multiphoton excitation at 750 and 800 nm. In this context, we discuss the potential applications of these complexes as visible/NIR light photoactivated carbon monoxide releasing moieties (photoCORMs). We also report the isolation and crystal structures of the TPYOH complexes Mn(TPYOH)Cl and Mn(TPYOH), to illustrate a possible photolysis product(s).
多光子激发使人们能够利用穿透组织的近红外（NIR）光进入高能激发态并在生物系统中执行有价值的任务。在此，我们描述了新的光活性三羰基锰配合物，其包含配体4'-对-N，N-双（2-羟乙基）氨基-苄基-2,2':6',2″-三联吡啶（TPYOH），它可作为双光子近红外激发的天线。Mn(CO)(TPYOH)X（X = Br或CFSO）配合物的溶液在可见光激发（405 nm，451 nm）下对CO释放具有很强的光活性。在750和800 nm处的多光子激发也引发了相同的响应。在此背景下，我们讨论了这些配合物作为可见光/近红外光光活化一氧化碳释放分子（光CORMs）的潜在应用。我们还报告了TPYOH配合物Mn(TPYOH)Cl和Mn(TPYOH)的分离及晶体结构，以说明可能的光解产物。
