运动干预可降低乳腺癌幸存者的加速度计测量的久坐时间。
Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention.
机构信息
Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, San Diego, CA, USA.
UC San Diego Moores Cancer Center, University of California, San Diego, La Jolla, San Diego, CA, USA.
出版信息
J Cancer Surviv. 2019 Jun;13(3):468-476. doi: 10.1007/s11764-019-00768-8. Epub 2019 May 29.
PURPOSE
Cancer survivors are highly sedentary and have low physical activity. How physical activity interventions impact sedentary behavior remains unclear. This secondary analysis examined changes in sedentary behavior among breast cancer survivors participating in a physical activity intervention that significantly increased moderate-to-vigorous physical activity (MVPA).
METHODS
Insufficiently active breast cancer survivors were randomized to a 12-week physical activity intervention (exercise arm) or control arm. The intervention focused solely on increasing MVPA with no content targeting sedentary behavior. Total sedentary behavior, light physical activity (LPA), and MVPA were measured at baseline and 12 weeks (ActiGraph GT3X+ accelerometer). Separate linear mixed-effects models tested intervention effects on sedentary behavior, intervention effects on LPA, the relationship between change in MVPA and change in sedentary behavior, and potential moderators of intervention effects on sedentary behavior.
RESULTS
The exercise arm had significantly greater reductions in sedentary behavior than the control arm (mean - 24.9 min/day (SD = 5.9) vs. - 4.8 min/day (SD = 5.9), b = - 20.1 (SE = 8.4), p = 0.02). Larger increases in MVPA were associated with larger decreases in sedentary behavior (b = - 1.9 (SE = 0.21), p < 0.001). Women farther out from surgery had significantly greater reductions in sedentary behavior than women closer to surgery (b = - 0.91 (SE = 0.5), p = 0.07). There was no significant group difference in change in LPA from baseline to 12 weeks (b = 5.64 (SE = 7.69), p = 0.48).
CONCLUSIONS
Breast cancer survivors in a physical activity intervention reduced total sedentary time in addition to increasing MVPA.
IMPLICATIONS FOR CANCER SURVIVORS
Both increasing physical activity and reducing sedentary behavior are needed to promote optimal health in cancer survivors. These results show that MVPA and sedentary behavior could be successfully targeted together, particularly among longer-term cancer survivors.
CLINICAL TRIAL REGISTRATION
This study is registered at www.ClinicalTrials.gov (NCT02332876).
目的
癌症幸存者普遍久坐，身体活动水平较低。身体活动干预对久坐行为的影响尚不清楚。本二次分析旨在研究参加显著增加中高强度体力活动（MVPA）的身体活动干预的乳腺癌幸存者中，久坐行为的变化情况。
方法
身体活动不足的乳腺癌幸存者被随机分配至 12 周身体活动干预（运动组）或对照组。干预仅专注于增加 MVPA，不针对久坐行为。使用 ActiGraph GT3X+加速度计在基线和 12 周时测量总久坐时间、低强度体力活动（LPA）和 MVPA。单独的线性混合效应模型检验了干预对久坐行为的影响、干预对 LPA 的影响、MVPA 变化与久坐行为变化之间的关系，以及干预对久坐行为影响的潜在调节因素。
结果
与对照组相比，运动组的久坐时间显著减少（平均减少 24.9 分钟/天（SD=5.9）比减少 4.8 分钟/天（SD=5.9），b=-20.1（SE=8.4），p=0.02）。MVPA 的较大增加与久坐时间的较大减少相关（b=-1.9（SE=0.21），p<0.001）。距离手术时间越远的女性比距离手术时间更近的女性有更大的减少（b=-0.91（SE=0.5），p=0.07）。从基线到 12 周时，两组之间的 LPA 变化没有显著差异（b=5.64（SE=7.69），p=0.48）。
结论
身体活动干预使乳腺癌幸存者不仅增加了 MVPA，还减少了总久坐时间。
对癌症幸存者的影响
增加身体活动和减少久坐行为都需要促进癌症幸存者的健康。这些结果表明，MVPA 和久坐行为可以同时成功地针对，特别是在长期癌症幸存者中。
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