Schörner W, Laniado M, Niendorf H P, Schubert C, Felix R
AJNR Am J Neuroradiol. 1986 Nov-Dec;7(6):1013-20.
Time-dependent changes in the contrast enhancement of tumor tissue, tumor necrosis, perifocal edema, and normal brain tissue after IV injection of 0.1 mmol gadolinium-DTPA/kg body weight were studied with spin-echo technique (SE 800/35) in 15 patients with intracranial tumors. Using a region of interest technique, we determined the signal-intensity values of these tissues before and at fixed times up to 68.5 min after administration of the contrast agent. In tumor tissue, the 8.5 min postinjection (p.i.) scan showed a significant increase in signal intensity. The signal intensity of the tumor tissue remained significantly higher than precontrast levels throughout the entire period of observation, decreasing only slightly toward the end of the examination (48.5 and 68.5 min p.i.). Central tumor necrosis exhibited a delayed uptake of the contrast agent, with a maximum signal intensity between 48.5 and 68.5 min p.i. In perifocal edema and normal brain tissue, slight increases in signal intensity after injection of gadolinium-DTPA were measured (statistically significant in the case of edema). This effect, however, was not visually detectable. The present study shows that after one injection, scans with excellent tumor visualization can be obtained between 8.5 and 38.5 min p.i. and with diagnostically valid enhancement at least up to 68.5 min p.i.
采用自旋回波技术（SE 800/35），对15例颅内肿瘤患者静脉注射0.1 mmol钆-二乙三胺五乙酸/千克体重后肿瘤组织、肿瘤坏死区、瘤周水肿及正常脑组织对比增强的时间依赖性变化进行了研究。使用感兴趣区技术，我们测定了这些组织在注射造影剂前及注射后至68.5分钟的固定时间点的信号强度值。在肿瘤组织中，注射后8.5分钟扫描显示信号强度显著增加。在整个观察期内，肿瘤组织的信号强度一直显著高于造影前水平，仅在检查结束时（注射后48.5和68.5分钟）略有下降。肿瘤中心坏死区对比剂摄取延迟，在注射后48.5至68.5分钟信号强度达到最大值。在瘤周水肿和正常脑组织中，注射钆-二乙三胺五乙酸后信号强度有轻微增加（水肿情况具有统计学意义）。然而，这种效应在视觉上无法检测到。本研究表明，单次注射后，在注射后8.5至38.5分钟可获得肿瘤显示良好的扫描图像，至少在注射后68.5分钟可获得具有诊断价值的强化图像。
