Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.
Sydney Medical School, University of Sydney, Sydney, NSW, 2005, Australia.
Mech Ageing Dev. 2019 Jun;180:82-88. doi: 10.1016/j.mad.2019.04.003. Epub 2019 Apr 10.
Frailty is a progressive, aging-related syndrome of unknown etiology characterized by increased susceptibility and decreased resilience to external stressors. Understanding underlying mechanisms and identifying interventions to improve resilience are major challenges in biogerontology. Adequate nutrition is central to organismal health and wellbeing and can be modulated to improve longevity. While there are clear associations between poor nutrition (excess or deficient calorie intake) and frailty in humans, only recently has the link between frailty and nutrition been addressed in experimental model systems in which causality and molecular mechanisms can be explored. Here we review the evidence linking nutrition to the frailty syndrome, including individual aspects such as muscle function, body composition and chronic disease, with a specific focus on mouse models and experimental nutritional interventions including dietary restriction.
衰弱是一种进行性的、与衰老相关的综合征，其病因不明，其特征是对外界应激源的易感性增加和弹性降低。了解潜在机制并确定改善弹性的干预措施是生物老年学的主要挑战。充足的营养是机体健康和幸福的核心，可以通过调节来延长寿命。虽然营养不良（过多或过少的热量摄入）与人类的衰弱之间存在明显的关联，但直到最近，在可以探索因果关系和分子机制的实验模型系统中，才解决了衰弱与营养之间的联系。在这里，我们回顾了将营养与衰弱综合征联系起来的证据，包括肌肉功能、身体成分和慢性疾病等个别方面，并特别关注了小鼠模型和包括饮食限制在内的实验性营养干预措施。
