拓展抗病毒药物的作用谱。

Expanding the activity spectrum of antiviral agents.

机构信息

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway.

Institute of Technology, University of Tartu, Tartu 50090, Estonia.

出版信息

Drug Discov Today. 2019 May;24(5):1224-1228. doi: 10.1016/j.drudis.2019.04.006. Epub 2019 Apr 10.

DOI:10.1016/j.drudis.2019.04.006

PMID:30980905

Abstract

Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs could reinforce the arsenal of available antiviral therapeutics pending the results of further pre-clinical and clinical studies.

摘要

广谱抗病毒药物（BSA）是指能够抑制多种人类病毒复制的药物。在这里，我们回顾了 108 种已批准、正在研究和实验性的 BSA，这些药物在人类中的安全性概况是可用的。在进一步的临床前和临床研究结果出来之前，最有效和耐受性最好的 BSA 可以增强现有的抗病毒治疗药物的储备。