Cell Structure Laboratory, National Center for Biotechnology, National Research Council, CNB-CSIC, Darwin 3, UAM, campus de Cantoblanco, 28049 Madrid, Spain.
Cell Structure Laboratory, National Center for Biotechnology, National Research Council, CNB-CSIC, Darwin 3, UAM, campus de Cantoblanco, 28049 Madrid, Spain.
Virus Res. 2019 Apr 15;264:22-31. doi: 10.1016/j.virusres.2019.02.011. Epub 2019 Feb 19.
Emerging viruses are a major threat to human health. Recent outbreaks have emphasized the urgent need for new antiviral treatments. For several pathogenic viruses, considerable efforts have focused on vaccine development. However, during epidemics infected individuals need to be treated urgently. High-throughput screening of clinically tested compounds provides a rapid means to identify undiscovered, antiviral functions for well-characterized therapeutics. Repurposed drugs can bypass part of the early cost and time needed for validation and authorization. In this review we describe recent efforts to find broad spectrum antivirals through drug repurposing. We have chosen several candidates and propose strategies to understand their mechanism of action and to determine how resistance to antivirals develops in infected cells.
新兴病毒是人类健康的主要威胁。最近的疫情爆发强调了急需新的抗病毒治疗方法。对于几种致病病毒，人们已经投入了相当大的精力来开发疫苗。然而，在疫情期间，感染的人需要紧急治疗。对临床测试化合物进行高通量筛选为鉴定具有良好特性的治疗药物中未被发现的抗病毒功能提供了快速手段。再利用药物可以绕过早期验证和授权所需的部分成本和时间。在这篇综述中，我们描述了通过再利用药物来寻找广谱抗病毒药物的最新进展。我们选择了一些候选药物，并提出了一些策略来了解它们的作用机制，并确定病毒感染细胞中抗病毒药物耐药性是如何发展的。
