Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Department of Vascular Surgery, Aalborg University Hospital, Aalborg, Denmark.
Proc Nutr Soc. 2020 Feb;79(1):22-29. doi: 10.1017/S0029665119000582. Epub 2019 Apr 15.
n-3 PUFA may exert favourable effects on several processes that may inhibit the atherosclerotic process. However, the role of n-3 PUFA in lowering the risk of atherosclerotic CVD (ASCVD) has been fiercely debated. In the present paper, we summarise the main findings from previous follow-up studies of intake and studies using adipose tissue as an objective biomarker to investigate exposure to n-3 PUFA in relation to ASCVD risk and discuss some perspectives for further research. The majority of previous studies investigating intake of marine- and plant-based n-3 PUFA have focused on CHD while other ASCVD such as ischaemic stroke and peripheral artery disease have been less studied. However, recent data from Danish Diet, Cancer and Health cohort suggest that marine n-3 PUFA may be inversely associated with risk of myocardial infarction, ischaemic stroke and peripheral arterial disease caused by atherosclerosis. The effect of the plant-derived n-3 PUFA α-linolenic acid on ASCVD is less clear and several gaps in the literature remain to be explored.
n-3PUFA 可能对几种可能抑制动脉粥样硬化过程的过程产生有利影响。然而，n-3PUFA 降低动脉粥样硬化性心血管疾病 (ASCVD) 风险的作用一直存在激烈争论。在本文中，我们总结了之前关于摄入量的随访研究和使用脂肪组织作为客观生物标志物来研究与 ASCVD 风险相关的 n-3PUFA 暴露的主要研究结果，并讨论了进一步研究的一些观点。以前研究摄入海洋和植物源性 n-3PUFA 的大多数研究都集中在冠心病上，而其他 ASCVD，如缺血性中风和外周动脉疾病，则研究较少。然而，来自丹麦饮食、癌症和健康队列的最新数据表明，海洋 n-3PUFA 可能与动脉粥样硬化引起的心肌梗死、缺血性中风和外周动脉疾病的风险呈负相关。植物源性 n-3PUFA α-亚麻酸对 ASCVD 的影响不太清楚，文献中仍存在一些空白需要探索。
