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不同年龄段与光老化相关的皮肤变化:应用生物物理和成像技术的临床评估。

Photoageing-related skin changes in different age groups: a clinical evaluation by biophysical and imaging techniques.

机构信息

School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

出版信息

Int J Cosmet Sci. 2019 Jun;41(3):265-273. doi: 10.1111/ics.12531. Epub 2019 May 26.

Abstract

OBJECTIVES

In view of the lack of studies about the morphological and structural changes caused by solar radiation in young people, the aim of the present study was to evaluate the photoageing-related changes in the skin of different age groups by biophysical and imaging techniques.

METHODS

Forty-four healthy female subjects were divided into two age groups: Group 1 (G1): 18-35 years old and Group 2 (G2): 40-60 years old. The skin of malar region of the face was evaluated in terms of mechanical properties, disorder in the pigmentation pattern, morphological and structural changes using the Cutometer , Colorimeter , Visioface and Dermascan C devices and reflectance confocal microscopy (Vivascope ).

RESULTS

The results showed that the main changes in the skin of G1 were related to the pigmentation pattern, the papilla format and depletion of thin collagen fibres. These alterations were also observed in the skin of G2, but with more pronounced effects.

CONCLUSION

The knowledge about the skin changes caused by photoageing obtained in this study is very important for the development of dermocosmetic products for more effective treatments particularly focused on this type of skin. Finally, objective characterization of photoageing showed the importance of photoprotective habits since the first years of life in order to retard the appearance of skin changes caused by solar radiation.

摘要

目的

鉴于目前缺乏关于太阳辐射对年轻人皮肤形态和结构变化的研究,本研究旨在通过生物物理和成像技术评估不同年龄段皮肤的光老化相关变化。

方法

将 44 名健康女性受试者分为两组:第 1 组(G1):18-35 岁;第 2 组(G2):40-60 岁。采用 Cutometer、Colorimeter、Visioface 和 Dermascan C 设备以及反射共聚焦显微镜(Vivascope)评估面部颧骨区域的皮肤机械性能、色素沉着模式紊乱、形态和结构变化。

结果

结果表明,G1 组皮肤的主要变化与色素沉着模式、乳头形成和薄胶原纤维耗竭有关。这些变化在 G2 组的皮肤中也观察到,但影响更明显。

结论

本研究获得的光老化引起的皮肤变化知识对于开发更有效的皮肤护理产品非常重要,特别是针对这种类型的皮肤。最后,光老化的客观特征表明,为了延缓太阳辐射引起的皮肤变化的出现,从生命的最初几年开始就养成防晒习惯非常重要。

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