Prema K S J, Prasad N D S, Kurien A A
Department of Pathology, Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India.
Department of Nephrology, Stanley Medical College, Royapuram, Chennai, Tamil Nadu, India.
Indian J Nephrol. 2019 Mar-Apr;29(2):122-124. doi: 10.4103/ijn.IJN_375_17.
In renal allograft recipients, cytomegalovirus (CMV) typically causes tubulointerstitial nephritis. Only rarely glomeruli are involved. We present a rare case of CMV with collapsing glomerulopathy, necrotizing glomerulonephritis, and crescent formation in a renal allograft recipient. Immunohistochemistry confirmed CMV infection. The patient was started on valganciclovir and his renal function remained stable. A repeat renal biopsy performed three months later showed morphologically normal glomeruli and CMV immunostaining was also negative. Nephropathologists have to carefully screen for CMV in cases with crescentic or collapsing glomerulopathy as the later lesions resolve after treating the underlying viral infection. This study will add on to the various glomerular changes associated with CMV infection.
在肾移植受者中，巨细胞病毒（CMV）通常引起肾小管间质性肾炎。肾小球受累极为罕见。我们报告了一例肾移植受者罕见的CMV感染病例，伴有塌陷性肾小球病、坏死性肾小球肾炎和新月体形成。免疫组化证实了CMV感染。患者开始使用缬更昔洛韦治疗，其肾功能保持稳定。三个月后进行的重复肾活检显示肾小球形态正常，CMV免疫染色也为阴性。肾病病理学家在诊断新月体性或塌陷性肾小球病时必须仔细筛查CMV，因为在治疗潜在病毒感染后，后者的病变会消退。本研究将补充与CMV感染相关的各种肾小球变化。
