Department of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, 70124 Bari, Italy.
Department of Interdisciplinary Medicine (DIM), University of Bari Aldo Moro, 70124 Bari, Italy.
Int J Mol Sci. 2023 Feb 15;24(4):3897. doi: 10.3390/ijms24043897.
The prokaryotic, viral, fungal, and parasitic microbiome exists in a highly intricate connection with the human host. In addition to eukaryotic viruses, due to the existence of various host bacteria, phages are widely spread throughout the human body. However, it is now evident that some viral community states, as opposed to others, are indicative of health and might be linked to undesirable outcomes for the human host. Members of the virome may collaborate with the human host to retain mutualistic functions in preserving human health. Evolutionary theories contend that a particular microbe's ubiquitous existence may signify a successful partnership with the host. In this Review, we present a survey of the field's work on the human virome and highlight the role of viruses in health and disease and the relationship of the virobiota with immune system control. Moreover, we will analyze virus involvement in glomerulonephritis and in IgA nephropathy, theorizing the molecular mechanisms that may be responsible for the crosslink with these renal diseases.
原核生物、病毒、真菌和寄生虫微生物组与人类宿主存在着高度复杂的联系。除了真核病毒外，由于宿主细菌的存在，噬菌体广泛分布于人体各处。然而，现在很明显，一些病毒群落状态与其他状态不同，表明健康状况，并可能与宿主的不良后果有关。病毒组的成员可能与人类宿主合作，以保持共生功能，维护人类健康。进化理论认为，一种特定微生物的普遍存在可能表明它与宿主建立了成功的伙伴关系。在这篇综述中，我们介绍了该领域对人类病毒组的研究，并强调了病毒在健康和疾病中的作用，以及病毒组与免疫系统控制的关系。此外，我们将分析病毒在肾小球肾炎和 IgA 肾病中的作用，推测可能导致与这些肾脏疾病发生交叉联系的分子机制。
