Chen Jun, Huang Wei, Cheng Chao-Hui, Zhou Lan, Jiang Guang-Bin, Hu Yuan-Yuan
Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Department of Radiology, Suizhou Central Hospital, Suizhou, China.
Front Neurol. 2019 Mar 28;10:290. doi: 10.3389/fneur.2019.00290. eCollection 2019.
A number of studies have reported that aldehyde dehydrogenase-2 () polymorphisms maybe associated with the risk of Alzheimer's disease (AD) and Parkinson's disease (PD). However, the results of such studies are inconsistent. We therefore conducted a meta-analysis to clarify the association between polymorphisms and the risk of AD and PD. Five online databases were searched and the relevant studies were reviewed from inception through May 10, 2018. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated in each genetic model of the general population and various subgroups. Furthermore, we simultaneously performed heterogeneity, cumulative, sensitivity, and publication bias analyses. Overall, nine case-control studies involving 5,315 subjects were included in this meta-analysis. Potential associations were found between the rs671 G>A polymorphism and the risk of AD (A vs. G: OR = 1.46, 95%CI = 1.01-2.11, = 0.05, = 84.2%; AA vs. GG: OR = 2.22, 95%CI = 1.03-4.77, = 0.04, = 79.2%; AA vs. GG+GA: OR = 1.94, 95%CI = 1.03-3.64, =0.04, = 71.1%). In addition, some similar results were observed in other subgroups. Moreover, no significant association between polymorphisms and PD risk. In conclusion, our meta-analysis indicated that the rs671 G>A polymorphism plays an important role in AD development.
多项研究报告称，乙醛脱氢酶2（ALDH2）基因多态性可能与阿尔茨海默病（AD）和帕金森病（PD）的发病风险相关。然而，此类研究结果并不一致。因此，我们进行了一项荟萃分析，以阐明ALDH2基因多态性与AD和PD发病风险之间的关联。检索了五个在线数据库，并对从数据库建立至2018年5月10日的相关研究进行了综述。在普通人群及各个亚组的每种遗传模型中计算比值比（OR）及相应的95%置信区间（CI）。此外，我们同时进行了异质性、累积性、敏感性和发表偏倚分析。总体而言，本荟萃分析纳入了9项涉及5315名受试者的病例对照研究。发现ALDH2基因rs671 G>A多态性与AD发病风险之间存在潜在关联（A与G相比：OR = 1.46，95%CI = 1.01 - 2.11，P = 0.05，I² = 84.2%；AA与GG相比：OR = 2.22，95%CI = 1.03 - 4.77，P = 0.04，I² = 79.2%；AA与GG + GA相比：OR = 1.94，95%CI = 1.03 - 3.64，P = 0.04，I² = 71.1%）。此外，在其他亚组中也观察到了一些类似结果。而且，未发现ALDH2基因多态性与PD发病风险之间存在显著关联。总之，我们的荟萃分析表明，ALDH2基因rs671 G>A多态性在AD发病过程中起重要作用。
