Mei Xiao-Fei, Hu Sheng-Da, Liu Peng-Fei, Li Fei, Zhou Xian-Yong, Zhou Ya-Feng, Chen Tan
Department of Cardiology, The First Affiliated Hospital of Soochow University.
Int Heart J. 2020 May 30;61(3):562-570. doi: 10.1536/ihj.19-259. Epub 2020 Apr 29.
Aldehyde dehydrogenase-2 (ALDH2) rs671 G>A polymorphism can influence the activity of ALDH2 and may be associated with the risk of essential hypertension (EH). Although many previous studies have explored such a relationship, the conclusion is still controversial.The PubMed, Embase, and China National Knowledge Infrastructure databases were searched on the ALDH2 gene and EH. We used the Newcastle-Ottawa Scale to evaluate the quality of the study. Then we calculated the strength of relationship between ALDH2 rs671 mutation and EH by utilizing odds ratios and 95% confidence intervals. Besides, subgroup analysis and sensitivity analysis were performed and the publication bias was assessed.There were 12 studies containing 8153 cases and 10,162 controls. Our meta-analysis showed significant association between ALDH2 rs671 polymorphism and EH in four genetic models (the allele model, the homozygote model, the heterozygote model, and the dominant model), whereas it did not indicate this connection in the recessive model. However, a trend of decreased risk still could be seen. Furthermore, we also found an obvious association between rs671 mutation and the risk of EH in the male group than in the female group in all five genetic models.We concluded that ALDH2 rs671 G>A polymorphism may decrease the risk of EH. Furthermore, susceptibility to EH reduced in males but not in females. As a variant in ALDH2, rs671 G>A could be an attractive candidate for genetic therapy of EH. In addition, more case-control studies should be conducted to strengthen our conclusion and evaluate the gene-gene and gene-environment interactions between the ALDH2 gene and EH.
乙醛脱氢酶2（ALDH2）rs671 G>A多态性可影响ALDH2的活性，并可能与原发性高血压（EH）的风险相关。尽管此前许多研究都探讨了这种关系，但其结论仍存在争议。我们在PubMed、Embase和中国知网数据库中检索了关于ALDH2基因和EH的研究。我们使用纽卡斯尔-渥太华量表评估研究质量。然后利用比值比和95%置信区间计算ALDH2 rs671突变与EH之间的关联强度。此外，进行了亚组分析和敏感性分析，并评估了发表偏倚。
共有12项研究，包含8153例病例和10162例对照。我们的荟萃分析显示，在四个遗传模型（等位基因模型、纯合子模型、杂合子模型和显性模型）中，ALDH2 rs671多态性与EH之间存在显著关联，而在隐性模型中未显示这种关联。然而，仍可看出风险降低的趋势。此外，我们还发现在所有五个遗传模型中，rs671突变与男性组EH风险的关联明显高于女性组。
我们得出结论，ALDH2 rs671 G>A多态性可能降低EH风险。此外，男性对EH的易感性降低，而女性则不然。作为ALDH2中的一个变体，rs671 G>A可能是EH基因治疗的一个有吸引力的候选基因。此外，应开展更多病例对照研究以加强我们的结论，并评估ALDH2基因与EH之间的基因-基因和基因-环境相互作用。
