Kim Jiwon, Kim Jihye, Kang Yunhee
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin, Gyeonggi 17104, Republic of Korea.
Center for Human Nutrition, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA.
Nutr Res Pract. 2019 Apr;13(2):141-149. doi: 10.4162/nrp.2019.13.2.141. Epub 2019 Feb 28.
BACKGROUND/OBJECTIVES: This study examined the association between refined grain consumption by subtype and the incidence of hypertension from the Korean Genome and Epidemiology Study data.
SUBJECTS/METHODS: In total, 5,018 participants (2,439 men and 2,579 women) from 40 to 69 years without hypertension were recruited at the beginning (2001-2002). Blood pressure and antihypertensive medication use were assessed biennially for the incidence of hypertension during the 8-year follow-up period (2009-2010). Hypertension was diagnosed as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or antihypertensive medication use. Dietary intake including refined grains was assessed by a food frequency questionnaire at baseline and the follow-up (2005-2006). A multivariate Cox proportional hazard model was used to examine hazard ratios (HRs) and 95% confidence intervals (CIs) for incident hypertension according to refined-grain consumption.
A total of 1,377 cases of hypertension (710 men and 667 women) were newly ascertained. Frequent noodle consumers (≥ 5 servings/week) among the women had a 2.3-fold higher risk of hypertension than infrequent noodle consumers after adjustment for potential confounders (HR = 2.31, 95% CI = 1.33-4.01, for trend = 0.0001). However, no significant association was found among the men. The intake of other refined grain products such as white rice and breads was not associated with the incidence of hypertension.
Frequent noodle consumption was positively associated with a risk of incident hypertension in South Korean women.
背景/目的:本研究利用韩国基因组与流行病学研究数据,探讨不同类型精制谷物消费与高血压发病率之间的关联。
对象/方法:2001年至2002年期间,共招募了5018名年龄在40至69岁之间、无高血压的参与者(男性2439名,女性2579名)。在8年随访期(2009年至2010年)内,每两年评估一次血压和抗高血压药物使用情况,以确定高血压的发病率。高血压的诊断标准为收缩压≥140 mmHg或舒张压≥90 mmHg或使用抗高血压药物。通过基线和随访(2005年至2006年)时的食物频率问卷评估包括精制谷物在内的饮食摄入量。采用多变量Cox比例风险模型,根据精制谷物消费情况,研究高血压发病的风险比(HR)和95%置信区间(CI)。
共新确诊1377例高血压病例(男性710例,女性667例)。在调整潜在混杂因素后,女性中频繁食用面条者(≥5份/周)患高血压的风险比不常食用面条者高2.3倍(HR = 2.31,95% CI = 1.33 - 4.01,趋势P = 0.0001)。然而,在男性中未发现显著关联。其他精制谷物产品如白米和面包的摄入量与高血压发病率无关。
在韩国女性中,频繁食用面条与高血压发病风险呈正相关。