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乳制品消费与韩国中老年成年人代谢综合征发病率较低相关:韩国基因组与流行病学研究(KoGES)。

Dairy consumption is associated with a lower incidence of the metabolic syndrome in middle-aged and older Korean adults: the Korean Genome and Epidemiology Study (KoGES).

作者信息

Kim Dasom, Kim Jihye

机构信息

Department of Medical Nutrition,Graduate School of East-West Medical Science,Kyung Hee University,Yongin 446-701,Republic of Korea.

出版信息

Br J Nutr. 2017 Jan;117(1):148-160. doi: 10.1017/S000711451600444X. Epub 2017 Jan 18.

DOI:10.1017/S000711451600444X
PMID:28098053
Abstract

This cohort study examined the association between total and individual dairy products and the risk of developing the metabolic syndrome (MetS) and its components in Korean adults from the Korean Genome and Epidemiology Study. We prospectively analysed 5510 participants aged 40-69 years without the MetS at baseline during a 10-year follow-up period. Dairy consumption was assessed with a semi-quantitative FFQ at baseline and after 4 years. The MetS was defined according to the criteria by the National Cholesterol Education Program Adult Treatment Panel III. The Cox's proportional hazard model was used to examine the association between consumption of total dairy products, milk and yogurt in servings per week and the risk of incident MetS or individual components. A total of 2103 subjects developed the MetS (38·2 %) during an average follow-up of 67·4 months (range 17-104 months). Frequent dairy consumption (>7 servings of total dairy and milk/week, ≥4 servings of yogurt/week) was associated with a reduced risk of incident MetS and its components. In the multivariable adjusted model, hazard ratios for the MetS were 0·51 (95 % CI 0·43, 0·61) for total dairy products, 0·50 (95 % CI 0·38, 0·66) for milk and 0·67 (95 % CI 0·57, 0·78) for yogurt in frequent consumers compared with non-consumers. An inverse association between milk/yogurt and low HDL-cholesterol was shown only in women. In conclusion, high consumption of individual dairy products including milk and yogurt as well as total dairy were associated with a reduced risk of incident MetS and individual components in Korean adults.

摘要

这项队列研究通过韩国基因组与流行病学研究,调查了韩国成年人食用各类乳制品及总乳制品与发生代谢综合征(MetS)及其各组分风险之间的关联。我们对5510名年龄在40 - 69岁、基线时无MetS的参与者进行了为期10年的随访分析。在基线和4年后,通过半定量食物频率问卷(FFQ)评估乳制品摄入量。MetS根据美国国家胆固醇教育计划成人治疗小组第三次报告的标准进行定义。采用Cox比例风险模型,研究每周食用总乳制品、牛奶和酸奶的份数与发生MetS或其单个组分风险之间的关联。在平均67.4个月(范围17 - 104个月)的随访期间,共有2103名受试者发生了MetS(38.2%)。经常食用乳制品(每周食用总乳制品和牛奶超过7份,每周食用酸奶≥4份)与发生MetS及其组分的风险降低相关。在多变量调整模型中,与不食用者相比,经常食用者发生MetS的风险比,总乳制品为0.51(95%可信区间0.43, 0.61),牛奶为0.50(95%可信区间0.38, 0.66),酸奶为0.67(95%可信区间0.57, 0.78)。仅在女性中,牛奶/酸奶与低高密度脂蛋白胆固醇之间呈负相关。总之,在韩国成年人中,高摄入量的包括牛奶和酸奶在内的各类乳制品以及总乳制品与发生MetS及其单个组分的风险降低相关。

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