Han Kaiyue, Su Xiaoling, Liu Jiang, Yao Fengcai, Lu FeiYan
Graduate School, Qinghai University, Xining, Qinghai, China.
Department of Cardiology, Qinghai Provincial People's Hospital, Xining, China.
Cardiol Res Pract. 2019 Mar 7;2019:6291964. doi: 10.1155/2019/6291964. eCollection 2019.
Increased red cell distribution width (RDW) can predict the incidence and mortality of cardiovascular diseases. However, there are limited data on the relationship between RDW and altitude and the subtype of atrial fibrillation (AF). We investigated the effects of altitude on RDW in patients with different types of AF.
A total of 303 patients with nonvalvular AF were included. Of these, 156 lived in low altitude (77 paroxysmal AF, PAF; 79 persistent AF, PeAF) and 147 in high altitude (77 paroxysmal AF, PAF; 70 persistent AF, PeAF). In these groups, baseline characteristics, complete blood counts, serum biochemistry, and echocardiography were evaluated. Multivariate logistic regression analysis was conducted to determine the independent predictors of AF at the different altitudes.
In both low and high altitudes, RDW and left atrial diameter (LAD) were higher in AF than control subjects ( < 0.05) and higher in persistent AF than paroxysmal AF ( < 0.05). Compared with any groups (PAF group, PeAF group, or control group) of low-altitude, RDW and LAD were found higher in high-altitude corresponding groups. Multivariate logistic regression analysis demonstrated that RDW, mean corpuscular volume (MCV), and LAD levels independently associated with AF patients in low altitude (RDW, OR 1.687, 95% CI 1.021-2.789; < 0.05), while in high altitude, RDW, MCV, creatinine (Cr), and LAD were independent predictors for AF patients (RDW, OR 1.755, 95% CI 1.179-2.613; < 0.05).
Elevated RDW levels may be an independent risk marker for nonvalvular AF, affected by type of AF and altitude.
红细胞分布宽度（RDW）升高可预测心血管疾病的发病率和死亡率。然而，关于RDW与海拔及房颤（AF）亚型之间关系的数据有限。我们研究了海拔对不同类型AF患者RDW的影响。
共纳入303例非瓣膜性AF患者。其中，156例生活在低海拔地区（77例阵发性AF，PAF；79例持续性AF，PeAF），147例生活在高海拔地区（77例阵发性AF，PAF；70例持续性AF，PeAF）。对这些组进行基线特征、全血细胞计数、血清生化和超声心动图评估。进行多因素逻辑回归分析以确定不同海拔AF的独立预测因素。
在低海拔和高海拔地区，AF患者的RDW和左心房直径（LAD）均高于对照组（<0.05），持续性AF患者高于阵发性AF患者（<0.05）。与低海拔的任何组（PAF组、PeAF组或对照组）相比，高海拔相应组的RDW和LAD更高。多因素逻辑回归分析表明，RDW、平均红细胞体积（MCV）和LAD水平与低海拔AF患者独立相关（RDW，OR 1.687，95%CI 1.021-2.789；<0.05），而在高海拔地区，RDW、MCV、肌酐（Cr）和LAD是AF患者的独立预测因素（RDW，OR 1.755，95%CI 1.179-2.613；<0.05）。
RDW水平升高可能是非瓣膜性AF的独立风险标志物，受AF类型和海拔影响。
