Tanaka Wataru, Yokoyama Daigo, Matsuura Yasushi, Nozaki Masahiko, Hirozawa Naoya, Kunitake Hisato, Sakono Masanobu, Sakakibara Hiroyuki
Graduate School of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai Nishi, Miyazaki 889-2192, Japan.
Miyazaki Prefectural Food Research and Development Center, 16500-2 Sadowara Cho, Miyazaki 880-0303, Japan.
Toxicol Rep. 2019 Mar 18;6:272-278. doi: 10.1016/j.toxrep.2019.03.005. eCollection 2019.
Blueberry leaf may contain multiple compounds with beneficial effects. We conducted a 90-day toxicity study in rats to evaluate the safety of consuming the leaves of rabbiteye blueberry ( Aiton; RB species). Powdered leaves were administered daily by oral gavage at doses of 500, 1000, and 2500 mg/kg body weight to male and female Sprague-Dawley rats for 90 days. Treatment did not result in death or changes in the behavior and external appearance of the animals. No alterations were observed in hematological and serum chemical parameters, urinalysis, food consumption, body weight gain, or absolute and relative organ weights at the end of the treatment period, with the exception of some leukocyte percentages in male rats treated with 500 and 1000 mg/kg blueberry leaf powder. The findings indicate that rabbiteye blueberry leaf is safe for consumption and should be investigated as a candidate functional food.
蓝莓叶可能含有多种具有有益作用的化合物。我们在大鼠中进行了一项为期90天的毒性研究，以评估食用兔眼蓝莓（艾顿；RB品种）叶子的安全性。将叶粉以500、1000和2500毫克/千克体重的剂量每日经口灌胃给予雄性和雌性斯普拉格-道利大鼠，持续90天。治疗未导致动物死亡或行为及外观变化。在治疗期结束时，血液学和血清化学参数、尿液分析、食物消耗、体重增加或绝对和相对器官重量均未观察到改变，但用500和1000毫克/千克蓝莓叶粉治疗的雄性大鼠的一些白细胞百分比除外。研究结果表明，兔眼蓝莓叶食用安全，应作为功能性食品候选物进行研究。
