Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Chungju-si 27478, Korea.
Nanotechnology Research Center, Konkuk University, Chungju-si 27478, Korea.
Nutrients. 2017 Oct 1;9(10):1089. doi: 10.3390/nu9101089.
Chronic low-grade inflammation plays a pivotal role in the pathogenesis of obesity, due to its associated chronic diseases such as type II diabetes, cardiovascular diseases, pulmonary diseases and cancer. Thus, targeting inflammation is an attractive strategy to counter the burden of obesity-induced health problems. Recently, food-derived bioactive compounds have been spotlighted as a regulator against various chronic diseases due to their low toxicity, as opposed to drugs that induce severe side effects. Here we describe the beneficial effects of dietary anthocyanins on obesity-induced metabolic disorders and inflammation. Red cabbage microgreen, blueberry, blackcurrant, mulberry, cherry, black elderberry, black soybean, chokeberry and jaboticaba peel contain a variety of anthocyanins including cyanidins, delphinidins, malvidins, pelargonidins, peonidins and petunidins, and have been reported to alter both metabolic markers and inflammatory markers in cells, animals, and humans. This review discusses the interplay between inflammation and obesity, and their subsequent regulation via the use of dietary anthocyanins, suggesting an alternative dietary strategy to ameliorate obesity and obesity associated chronic diseases.
慢性低度炎症在肥胖症的发病机制中起着关键作用，因为它与 II 型糖尿病、心血管疾病、肺部疾病和癌症等相关慢性疾病有关。因此，针对炎症是对抗肥胖引起的健康问题负担的一种有吸引力的策略。最近，由于其低毒性，与诱导严重副作用的药物相反，源自食物的生物活性化合物已成为对抗各种慢性疾病的调节剂而备受关注。在这里，我们描述了膳食花色苷对肥胖引起的代谢紊乱和炎症的有益作用。紫甘蓝芽、蓝莓、黑加仑、桑椹、樱桃、黑接骨木、黑豆、黑果枸杞和嘉宝果果皮含有多种花色苷，包括氰苷、飞燕草苷、锦葵素、天竺葵素、芍药苷和矮牵牛苷，已被报道可改变细胞、动物和人类的代谢标志物和炎症标志物。这篇综述讨论了炎症和肥胖之间的相互作用，以及通过使用膳食花色苷对其进行的后续调节，这表明了一种替代饮食策略来改善肥胖和肥胖相关的慢性疾病。
