沙特阿拉伯沙克拉大学学生胃食管反流病的患病率及危险因素
Prevalence and risk factors of gastroesophageal reflux disease among Shaqra University students, Saudi Arabia.
作者信息
Alrashed Abdulaziz A, Aljammaz Khalid I, Pathan Aslam, Mandili Aeshah A, Almatrafi Samah A, Almotire Mashaeel H, Bahkali Salha M
机构信息
College of Medicine, Shaqra University, Shaqra, Saudi Arabia.
Department of Pharmacology and Therapeutics, College of Medicine, Sahqra University, Shaqra, Saudi Arabia.
出版信息
J Family Med Prim Care. 2019 Feb;8(2):462-467. doi: 10.4103/jfmpc.jfmpc_443_18.
INTRODUCTION
Gastroesophageal reflux disease (GERD) is one of the most common chronic gastrointestinal disorders in adults, it develops when the stomach contents reflux and rise up into the esophagus as a result from lower esophageal sphincter dysfunction. Stomach acid that touches the lining of the esophagus causes symptoms and complications. The classical symptoms of GERD include heartburn, usually after eating, chest pain, and regurgitation.
AIM
To measure the prevalence of gastroesophageal reflux disease and determine its risk factors among the students of Shaqra University.
METHODS
A cross-sectional study was conducted using a structured questionnaire distributed among Shaqra University students after multistage stratification and random sampling technique to stratify students according to gender and the three main colleges in Shaqra city, Saudi Arabia. The sample size was determined to be 435 with the precision of ± 5% and a 95% confidence interval (CI). The questionnaire included demographic data like age, gender, height and weight, lifestyle, and dietary habits. Statistical data were analyzed using the Statistical Package for Social Sciences (SPSS) version 16. Results with a value of <0.05 were considered statistically significant.
RESULTS
A total of 400 [227 (56%) male and 173 (43%) female] participants were evaluated. And 95 participants got a gastroesophageal reflux disease questionnaire score of ≥8 thus determining the prevalence of GERD to be 23.8%. Univariate analysis revealed that gender, smoking, familial history of GERD, high body mass index (>25 kg/m), fast food, tea, carbonated beverages consumption, quick eating, and sleeping within 1 hour of dinner are associated with symptomatic GERD ( < 0.05).
CONCLUSION
The results show a high prevalence of GERD in Shaqra university students and the presence of many modifiable risk factors which merits the conduction of public health campaigns to raise awareness about the disease and its risk factors.
引言
胃食管反流病（GERD）是成人中最常见的慢性胃肠疾病之一，当胃内容物因食管下括约肌功能障碍而反流至食管时发病。接触食管黏膜的胃酸会引发症状和并发症。GERD的典型症状包括通常在进食后出现的烧心、胸痛和反流。
目的
测量沙特阿拉伯沙克拉大学学生中胃食管反流病的患病率并确定其危险因素。
方法
采用多阶段分层随机抽样技术，根据性别和沙特阿拉伯沙克拉市的三所主要学院对学生进行分层，使用结构化问卷对沙克拉大学学生进行横断面研究。样本量确定为435，精度为±5%，置信区间为95%（CI）。问卷包括年龄、性别、身高和体重等人口统计学数据、生活方式和饮食习惯。使用社会科学统计软件包（SPSS）16版对统计数据进行分析。P值<0.05的结果被认为具有统计学意义。
结果
共评估了400名参与者[227名（56%）男性和173名（43%）女性]。95名参与者的胃食管反流病问卷得分≥8，因此确定GERD患病率为23.8%。单因素分析显示，性别、吸烟、GERD家族史、高体重指数（>25kg/m²）、快餐、茶、碳酸饮料消费、进食快以及晚餐后1小时内睡觉与症状性GERD相关（P<0.05）。
结论
结果显示沙克拉大学学生中GERD患病率较高，且存在许多可改变的危险因素，这值得开展公共卫生运动以提高对该疾病及其危险因素的认识。
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