在HIV/HCV合并感染患者中，成功的直接抗病毒治疗未能恢复循环中的黏膜相关恒定T细胞。 - Suppr

Successful direct-acting antiviral therapy in HIV/HCV co-infected patients fails to restore circulating mucosal-associated invariant T cells.

作者信息

Cannizzo Elvira Stefania, Cerrone Maddalena, Merlini Esther, van Wilgenburg Bonnie, Swadling Leo, Ancona Giuseppe, De Bona Anna, d'Arminio Monforte Antonella, Klenerman Paul, Marchetti Giulia

机构信息

Department of Health Sciences, Clinic of Infectious Diseases, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.

Imperial College London, London, UK.

出版信息

Eur J Immunol. 2019 Jul;49(7):1127-1129. doi: 10.1002/eji.201948152. Epub 2019 May 14.

DOI:10.1002/eji.201948152

PMID:30985000

Abstract

摘要

相似文献

Successful direct-acting antiviral therapy in HIV/HCV co-infected patients fails to restore circulating mucosal-associated invariant T cells.在HIV/HCV合并感染患者中，成功的直接抗病毒治疗未能恢复循环中的黏膜相关恒定T细胞。

Eur J Immunol. 2019 Jul;49(7):1127-1129. doi: 10.1002/eji.201948152. Epub 2019 May 14.

Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy.慢性丙型肝炎病毒（HCV）感染、人类免疫缺陷病毒（HIV）感染及HCV/HIV合并感染患者循环黏膜相关恒定T细胞（MAIT细胞）频率降低，且治疗期间未恢复。

PLoS One. 2016 Jul 14;11(7):e0159243. doi: 10.1371/journal.pone.0159243. eCollection 2016.

Impact of hepatitis C viral replication on CD4+ T-lymphocyte progression in HIV-HCV coinfection before and after antiretroviral therapy.抗反转录病毒治疗前后 HIV-HCV 合并感染中丙型肝炎病毒复制对 CD4+ T 淋巴细胞进展的影响。

AIDS. 2010 Jul 31;24(12):1857-65. doi: 10.1097/QAD.0b013e32833adbb5.

Strategies for assignment of HIV-HCV genotype-1-coinfected patients to either dual-therapy or direct-acting antiviral agent-based triple-therapy.将HIV-HCV基因1型合并感染患者分配至双重疗法或基于直接作用抗病毒药物的三重疗法的策略。

Antivir Ther. 2014;19(4):407-14. doi: 10.3851/IMP2717. Epub 2013 Dec 17.

HCV viraemia associates with NK cell activation and dysfunction in antiretroviral therapy-treated HIV/HCV-co-infected subjects.在接受抗逆转录病毒治疗的HIV/HCV合并感染患者中，丙型肝炎病毒血症与自然杀伤细胞激活及功能障碍有关。

J Viral Hepat. 2017 Oct;24(10):865-876. doi: 10.1111/jvh.12714. Epub 2017 May 11.

Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients.丙型肝炎病毒/艾滋病病毒合并感染患者接受联合抗逆转录病毒治疗后丙型肝炎病毒复制的调节

Sci Transl Med. 2014 Jul 23;6(246):246ra98. doi: 10.1126/scitranslmed.3008195.

Higher Activation in CD4(+) T Cells But Similar Viral Control Among HIV/Hepatitis C Virus-Coinfected Patients on a Simplification Monotherapy.在接受简化单一疗法的HIV/丙型肝炎病毒合并感染患者中，CD4(+) T细胞激活增强但病毒控制情况相似。

AIDS Res Hum Retroviruses. 2016 Jan;32(1):6-11. doi: 10.1089/AID.2014.0299. Epub 2015 Oct 21.

Successful direct-acting antiviral therapy improves circulating mucosal-associated invariant T cells in patients with chronic HCV infection.直接作用抗病毒疗法可改善慢性丙型肝炎感染患者的循环黏膜相关不变 T 细胞。

PLoS One. 2020 Dec 31;15(12):e0244112. doi: 10.1371/journal.pone.0244112. eCollection 2020.

Mucosal-associated invariant T-cell frequency and function in blood and liver of HCV mono- and HCV/HIV co-infected patients with advanced fibrosis.在伴有晚期纤维化的 HCV 单感染和 HCV/HIV 共感染患者的血液和肝脏中，黏膜相关不变 T 细胞的频率和功能。

Liver Int. 2018 Mar;38(3):458-468. doi: 10.1111/liv.13544. Epub 2017 Sep 16.

Transient liver injury associated with the early recovery of HCV-specific T-cell responses and HCV rebound in HIV-1/HCV coinfected patients undergoing highly active antiretroviral therapy.与 HIV-1/HCV 合并感染患者接受高效抗逆转录病毒治疗后 HCV 特异性 T 细胞反应早期恢复和 HCV 反弹相关的短暂性肝损伤。

J Acquir Immune Defic Syndr. 2013 Feb 1;62(2):135-42. doi: 10.1097/QAI.0b013e3182752d20.

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Hepatocellular Carcinoma Incidences and Risk Factors in Hepatitis C Patients: Interferon versus Direct-Acting Agents.丙型肝炎患者肝细胞癌的发病率和危险因素：干扰素与直接作用药物。

Viruses. 2024 Sep 18;16(9):1485. doi: 10.3390/v16091485.

Emerging features of MAIT cells and other unconventional T cell populations in human viral disease and vaccination.人病毒性疾病和疫苗接种中 MAIT 细胞和其他非常规 T 细胞群体的新特征。

Semin Immunol. 2022 Nov;61-64:101661. doi: 10.1016/j.smim.2022.101661. Epub 2022 Oct 28.

Gamma-Delta T-Cell Phenotype and Function in DAA-Treated HIV-HCV Co-Infected and HCV-Mono-Infected Subjects.DAA 治疗的 HIV-HCV 共感染和 HCV 单感染受试者中的 γδ T 细胞表型和功能。

Viruses. 2022 Jul 22;14(8):1594. doi: 10.3390/v14081594.

Immunological Mechanisms for Hepatocellular Carcinoma Risk after Direct-Acting Antiviral Treatment of Hepatitis C Virus Infection.丙型肝炎病毒感染直接抗病毒治疗后肝细胞癌风险的免疫机制

J Clin Med. 2021 Jan 10;10(2):221. doi: 10.3390/jcm10020221.

Liver Abnormalities after Elimination of HCV Infection: Persistent Epigenetic and Immunological Perturbations Post-Cure.丙型肝炎病毒感染清除后的肝脏异常：治愈后持续存在的表观遗传和免疫扰动

Pathogens. 2021 Jan 7;10(1):44. doi: 10.3390/pathogens10010044.

PLoS One. 2020 Dec 31;15(12):e0244112. doi: 10.1371/journal.pone.0244112. eCollection 2020.

Reversal of Immunity After Clearance of Chronic HCV Infection-All Reset?慢性 HCV 感染清除后的免疫逆转——一切重置？

Front Immunol. 2020 Oct 8;11:571166. doi: 10.3389/fimmu.2020.571166. eCollection 2020.

Lymphocyte Landscape after Chronic (HCV) Cure: The New Normal.慢性丙型肝炎（HCV）治愈后的淋巴细胞景观：新常态。

Int J Mol Sci. 2020 Oct 10;21(20):7473. doi: 10.3390/ijms21207473.

Hepatocellular Carcinoma Mechanisms Associated with Chronic HCV Infection and the Impact of Direct-Acting Antiviral Treatment.与慢性丙型肝炎病毒感染相关的肝细胞癌机制及直接抗病毒治疗的影响

J Hepatocell Carcinoma. 2020 Apr 15;7:45-76. doi: 10.2147/JHC.S221187. eCollection 2020.

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Successful direct-acting antiviral therapy in HIV/HCV co-infected patients fails to restore circulating mucosal-associated invariant T cells.

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