Curatolo P, Brinchi V, Cusmai R, Vignetti P, Benedetti P
Eur J Pediatr. 1986 Oct;145(5):439-42. doi: 10.1007/BF00439256.
To investigate the mutagenic effects of antiepileptic drugs (AED), 39 epileptic children treated by long-term monotherapy (10 cases with Pb, 11 with Cbz, 9 with Vpa, 8 with Pht) have been studied. The long-term administration was monitored by measurement of AED serum concentrations by gaschromatography. Metaphase chromosome observations were performed using short time culture of peripheral blood lymphocytes and 100 mitoses from each proband were analyzed. A significant increase of CA in the group of patients with Pb (0.23), Cbz (0.19), Vpa (0.25), Pht (0.18) as compared with those of nine epileptic children without treatment (0.08) has been found. Because unrepaired damage of DNA may act as a possible carcinogenic potential, the shortest possible duration of AED treatment is recommended.
为研究抗癫痫药物（AED）的致突变作用，我们对39例接受长期单一疗法治疗的癫痫患儿进行了研究（10例使用苯巴比妥，11例使用卡马西平，9例使用丙戊酸，8例使用苯妥英）。通过气相色谱法测量AED血清浓度来监测长期用药情况。采用外周血淋巴细胞短期培养进行中期染色体观察，并对每个先证者的100个有丝分裂进行分析。结果发现，与9例未接受治疗的癫痫患儿（0.08）相比，使用苯巴比妥（0.23）、卡马西平（0.19）、丙戊酸（0.25）、苯妥英（0.18）的患儿组中染色体畸变率显著增加。由于未修复的DNA损伤可能具有潜在致癌性，因此建议尽可能缩短AED治疗疗程。
