• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

接受卡马西平和苯妥英单药治疗的癫痫患者的染色体损伤。

Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin.

作者信息

Herha J, Obe G

出版信息

Hum Genet. 1976 Dec 15;34(3):255-63. doi: 10.1007/BF00295288.

DOI:10.1007/BF00295288
PMID:1002148
Abstract

We analyzed the leukocyte chromosomes of 10 epileptic probands on monotherapy with carbamazepine (CP), of 14 epileptic probands on monotherapy with diphenylhydantoin (DPH) and of 20 clinically normal probands (controls, CO). In the CP and in the DPH group we found a significant elevation of exchange-type aberrations as compared to the CO group. In the CP group we found predominantly chromatid translocations, in the DPH group exclusively dicentric chromosomes.

摘要

我们分析了10名单用卡马西平（CP）治疗的癫痫先证者、14名单用苯妥英（DPH）治疗的癫痫先证者以及20名临床正常先证者（对照组，CO）的白细胞染色体。与CO组相比，我们发现CP组和DPH组中交换型畸变显著增加。在CP组中，主要发现染色单体易位，而在DPH组中仅发现双着丝粒染色体。

相似文献

1
Chromosomal damage in epileptics on monotherapy with carbamazepine and diphenylhydantoin.接受卡马西平和苯妥英单药治疗的癫痫患者的染色体损伤。
Hum Genet. 1976 Dec 15;34(3):255-63. doi: 10.1007/BF00295288.
2
Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications.子宫内暴露于苯妥英钠和卡马西平单一疗法的儿童的研究结果：癫痫和药物的独立影响。
Am J Med Genet. 1997 Jan 10;68(1):18-24.
3
Prolonged use of phenytoin, carbamazepine or valproate monotherapy on plasma levels of folate and B(12): a comparison between epileptic patients with or without cardiovascular disorders.苯妥英、卡马西平或丙戊酸单药长期使用对叶酸和维生素B12血浆水平的影响：有或无心血管疾病的癫痫患者之间的比较
Neuro Endocrinol Lett. 2006 Feb-Apr;27(1-2):85-8.
4
Carbamazepine and phenytoin. Comparison of cognitive effects in epileptic patients during monotherapy and withdrawal.卡马西平和苯妥英钠。癫痫患者单药治疗及撤药期间认知效应的比较。
Arch Neurol. 1988 Aug;45(8):892-4. doi: 10.1001/archneur.1988.00520320082020.
5
Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin.对接受苯巴比妥和/或苯妥英治疗的癫痫患者外周血进行的染色体研究。
Food Chem Toxicol. 1984 Dec;22(12):1009-12. doi: 10.1016/0278-6915(84)90151-0.
6
A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.通过改进的X射线密度测定技术对抗惊厥药物引起的骨质脱矿进行定量测定。
Neuroradiology. 1983;25(5):315-8. doi: 10.1007/BF00439210.
7
The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase.苯妥英钠和卡马西平长期抗惊厥治疗对血清γ-谷氨酰转移酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶和碱性磷酸酶的影响。
Eur Arch Psychiatry Neurol Sci. 1988;237(5):312-6. doi: 10.1007/BF00450552.
8
[Altered gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase serum activities in long-term anticonvulsive therapy--comparison of diphenylhydantoin and carbamazepine].[长期抗惊厥治疗中γ-谷氨酰转移酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶和碱性磷酸酶血清活性的改变——苯妥英钠与卡马西平的比较]
Wien Klin Wochenschr. 1988 Oct 21;100(20):680-3.
9
[Serum lipids. lipoproteins, and apolipoproteins in adult epileptics treated with carbamazepine, valproic acid, or phenytoin].[接受卡马西平、丙戊酸或苯妥英治疗的成年癫痫患者的血脂、脂蛋白和载脂蛋白]
Rev Neurol. 1998 Nov;27(159):785-9.
10
A comparative controlled study between carbamazepine and diphenylhydantoin in psychomotor epilepsy.卡马西平与苯妥英钠治疗精神运动性癫痫的对照研究
Epilepsia. 1976 Jun;17(2):169-76. doi: 10.1111/j.1528-1157.1976.tb03394.x.

引用本文的文献

1
Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone.癫痫患儿在苯妥英或扑米酮长期治疗期间的染色体研究。
Hum Genet. 1981;56(3):345-8. doi: 10.1007/BF00274690.
2
Increased chromosomal breakage in epileptic children after long-term treatment.长期治疗后癫痫患儿染色体断裂增加。
Eur J Pediatr. 1986 Oct;145(5):439-42. doi: 10.1007/BF00439256.
3
Chromosomal aberrations in heavy smokers.重度吸烟者的染色体畸变

本文引用的文献

1
Determination of diphenylhydantoin and phenobarbital in small amounts of serum.微量血清中苯妥英和苯巴比妥的测定
J Lab Clin Med. 1963 Mar;61:501-7.
2
[Chromosome studies in persons treated with anticonvulsant drugs].[接受抗惊厥药物治疗者的染色体研究]
Humangenetik. 1972;16(3):209-16. doi: 10.1007/BF00273466.
3
The human leukocyte test system. I. DNA synthesis and mitoses in PHA-stimulated 2-day cultures.人类白细胞检测系统。I. 植物血凝素刺激的2日龄培养物中的DNA合成与有丝分裂。
Hum Genet. 1978 Apr 24;41(3):259-63. doi: 10.1007/BF00284759.
4
Beta-thalassaemia: increased chromosomal anomalies in lymphocyte cultures.β地中海贫血：淋巴细胞培养中染色体异常增加。
J Med Genet. 1979 Feb;16(1):52-5. doi: 10.1136/jmg.16.1.52.
5
Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy.对接受二丙乙酸单药治疗的失神癫痫患儿进行的染色体研究。
Hum Genet. 1978 Sep 19;43(3):329-31. doi: 10.1007/BF00278841.
Mutat Res. 1974 May;23(2):279-81.
4
Do anticonvulsants have a teratogenic effect?抗惊厥药有致畸作用吗？
Arch Neurol. 1974 Dec;31(6):364-73. doi: 10.1001/archneur.1974.00490420030002.
5
The human leulocyte test system. VII. Further investigations concerning micronucleus-derived premature chromosome condensation.人类白细胞测试系统。VII. 关于微核衍生的早熟染色体凝聚的进一步研究。
Humangenetik. 1975 Nov 6;30(2):143-54. doi: 10.1007/BF00291947.
6
Proceedings: Cytogenetic testing of antiepileptic drugs in human patients.论文集：抗癫痫药物在人类患者中的细胞遗传学检测
Mutat Res. 1975 Aug;29(2):179. doi: 10.1016/0027-5107(75)90170-0.
7
The human leukocyte test system. V. DNA synthesis and mitoses in PHA-stimulated 3-day cultures.人类白细胞检测系统。V. 植物血凝素刺激的3天培养物中的DNA合成与有丝分裂
Humangenetik. 1975 Aug 25;28(4):295-302.
8
Chromosomal damage in chronic alcohol users.慢性酒精使用者的染色体损伤。
Humangenetik. 1975 Sep 23;29(3):191-200. doi: 10.1007/BF00297623.
9
[Effects of anticonvulsive treatment on drug elimination in man. Induction of liver hydroxylating enzyme system by diphenylhydantoin and carbamazepine].[抗惊厥治疗对人体药物消除的影响。苯妥英钠和卡马西平对肝脏羟化酶系统的诱导作用]
Bibl Psychiatr. 1975(151):76-81.
10
The importance of individual pharmacokinetic data for treatment of epilepsy with carbamazepine.个体药代动力学数据在卡马西平治疗癫痫中的重要性。
Int J Clin Pharmacol Biopharm. 1976 Sep;14(2):144-8.