Department of Hematology, Henan Institute of Haematology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
Eur J Haematol. 2019 Jul;103(1):3-9. doi: 10.1111/ejh.13237. Epub 2019 May 29.
Multiple myeloma (MM) is still an incurable disease, and its pathogenesis involves cytogenetics and epigenetics. In recent years, the roles of long non-coding RNAs (lncRNAs) in MM have been deeply studied by scholars. LncRNAs are defined as a class of non-protein-coding transcripts greater than 200 nucleotides in length, which are involved in a large spectrum of biological processes, including proliferation, differentiation, apoptosis, invasion, and chromatin remodeling. However, little is known about the specific mechanisms of these lncRNAs. They can act as oncogenic and/or tumor-suppressive factors in the development and progression of MM. But that how do they work remains unclear. In this review, the recent progress in the study of functional lncRNAs associated with MM was summarized and the present knowledge about their expression and roles was discussed, to provide guidance for the in-depth functional study of lncRNAs.
多发性骨髓瘤（MM）仍然是一种无法治愈的疾病，其发病机制涉及细胞遗传学和表观遗传学。近年来，学者们深入研究了长链非编码 RNA（lncRNA）在 MM 中的作用。lncRNA 被定义为一类长度大于 200 个核苷酸的非蛋白编码转录本，参与了包括增殖、分化、凋亡、侵袭和染色质重塑在内的广泛生物学过程。然而，这些 lncRNA 的具体机制还知之甚少。它们在 MM 的发生和发展过程中可以作为癌基因和/或肿瘤抑制因子发挥作用。但它们的作用机制尚不清楚。在这篇综述中，总结了与 MM 相关的功能 lncRNA 的最新研究进展，并讨论了它们的表达和作用的现有知识，为深入研究 lncRNA 的功能提供了指导。
