Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Henan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Int J Oncol. 2023 Jun;62(6). doi: 10.3892/ijo.2023.5517. Epub 2023 May 5.
Multiple myeloma (MM) is one of the three major malignancies of the hematological system in middle‑aged and older individuals. The incidence of MM increases with age and due to its drug resistance and high recurrence, MM seriously harms human health. Long non‑coding RNAs (lncRNAs) are RNA molecules with a length of >200 nt and rarely encode proteins. Numerous studies reported that lncRNAs regulate carcinogenesis and cancer progression. MM‑associated lncRNAs affect features of tumor cells, including proliferation, apoptosis, adhesion and treatment resistance. The present review aims to summarize the latest findings on the roles of lncRNAs in MM to deepen the understanding of this field and provide insight for developing specific diagnostic tools and effective treatment strategies for MM, including novel biomarkers and targeted lncRNA therapeutics.
多发性骨髓瘤（MM）是中老年人群中血液系统三大恶性肿瘤之一。MM 的发病率随年龄增长而增加，且由于其耐药性和高复发率，严重危害人类健康。长链非编码 RNA（lncRNA）是一种长度大于 200nt 的 RNA 分子，很少编码蛋白质。大量研究表明 lncRNA 可调节癌发生和癌症进展。与 MM 相关的 lncRNA 影响肿瘤细胞的特征，包括增殖、凋亡、黏附和治疗耐药性。本综述旨在总结 lncRNA 在 MM 中的作用的最新发现，以加深对该领域的认识，并为开发 MM 的特异性诊断工具和有效治疗策略提供思路，包括新型生物标志物和靶向 lncRNA 治疗。
