Carrelo Henrique, Escoval André R, Vieira Tânia, Jiménez-Rosado Mercedes, Silva Jorge Carvalho, Romero Alberto, Soares Paula Isabel P, Borges João Paulo
CENIMAT/i3N, Department of Materials Science, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal.
CENIMAT/i3N, Department of Physics, NOVA School of Science and Technology (FCT NOVA), Campus de Caparica, 2829-516 Caparica, Portugal.
Gels. 2023 Dec 15;9(12):982. doi: 10.3390/gels9120982.
Cancer is a disease that continues to greatly impact our society. Developing new and more personalized treatment options is crucial to decreasing the cancer burden. In this study, we combined magnetic polysaccharide microparticles with a Pluronic thermoresponsive hydrogel to develop a multifunctional, injectable drug delivery system (DDS) for magnetic hyperthermia applications. Gellan gum and alginate microparticles were loaded with superparamagnetic iron oxide nanoparticles (SPIONs) with and without coating. The magnetic microparticles' registered temperature increases up to 4 °C upon the application of an alternating magnetic field. These magnetic microparticles were mixed with drug-loaded microparticles, and, subsequently, this mixture was embedded within a Pluronic thermoresponsive hydrogel that is capable of being in the gel state at 37 °C. The proposed DDS was capable of slowly releasing methylene blue, used as a model drug, for up to 9 days. The developed hydrogel/microparticle system had a smaller rate of drug release compared with microparticles alone. This system proved to be a potential thermoresponsive DDS suitable for magnetic hyperthermia applications, thus enabling a synergistic treatment for cancer.
癌症是一种持续对我们社会产生重大影响的疾病。开发新的、更具个性化的治疗方案对于减轻癌症负担至关重要。在本研究中，我们将磁性多糖微粒与普朗尼克热响应水凝胶相结合，开发了一种用于磁热疗应用的多功能可注射药物递送系统（DDS）。结冷胶和海藻酸盐微粒分别负载有有无涂层的超顺磁性氧化铁纳米颗粒（SPIONs）。施加交变磁场时，磁性微粒记录到的温度升高可达4°C。这些磁性微粒与载药微粒混合，随后将该混合物包埋于在37°C时能够呈凝胶状态的普朗尼克热响应水凝胶中。所提出的DDS能够将用作模型药物的亚甲蓝缓慢释放长达9天。与单独的微粒相比，所开发的水凝胶/微粒系统具有更低的药物释放速率。该系统被证明是一种适用于磁热疗应用的潜在热响应DDS，从而能够实现癌症的协同治疗。
