The United Graduate School of Agricultural Science, Gifu University, Gifu 501-1193, Japan.
Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan.
Toxins (Basel). 2019 Apr 3;11(4):200. doi: 10.3390/toxins11040200.
, a member of the species complex, stands out as a rice bakanae disease pathogen with a high production of gibberellic acid. Not all, but some strains are known to produce a carcinogenic mycotoxin fumonisin. Fumonisin biosynthesis is dependent on the FUM cluster composed of 16 genes. The FUM cluster was detected not only from a fumonisin producing strain, but also from a fumonisin nonproducing strain that does not produce a detectable level of fumonisin. Genetic mapping indicated the causative mutation(s) of fumonisin nonproduction is present in the FUM cluster of the fumonisin nonproducing strain. Comparative analyses of genes between the fumonisin producing and the nonproducing strains and gene complementation indicated that causative mutation of fumonisin nonproduction is not a single occurrence and the mutations are distributed in and . Our research revealed a natural variation in the FUM cluster involving fumonisin production difference in .
尖镰孢菌复合种的一个成员，作为一种能够大量产生赤霉素的水稻恶苗病菌而引人注目。并非所有的 菌株都能产生致癌的真菌毒素伏马菌素，但有一些菌株确实能产生伏马菌素。伏马菌素的生物合成依赖于由 16 个基因组成的 FUM 簇。不仅从产伏马菌素的菌株中检测到 FUM 簇，而且从不产生可检测水平伏马菌素的非产伏马菌素菌株中也检测到 FUM 簇。遗传图谱表明，非产伏马菌素的致病变异存在于非产伏马菌素菌株的 FUM 簇中。对产伏马菌素和非产伏马菌素菌株之间的 基因进行比较分析和基因互补表明，非产伏马菌素的致病变异不是单一发生的，突变分布在 和 中。我们的研究揭示了 FUM 簇中的一种自然变异，涉及到 中伏马菌素产生的差异。
