Chiara Matteo, Fanelli Francesca, Mulè Giuseppina, Logrieco Antonio F, Pesole Graziano, Leslie John F, Horner David S, Toomajian Christopher
Department of Biosciences, University of Milan, Italy Institute of Biomembranes and Bioenergetics, National Research Council, Bari, Italy.
Institute of Sciences of Food Production, National Research Council, Bari, Italy.
Genome Biol Evol. 2015 Oct 15;7(11):3062-9. doi: 10.1093/gbe/evv198.
Comparisons of draft genome sequences of three geographically distinct isolates of Fusarium fujikuroi with two recently published genome sequences from the same species suggest diverse profiles of secondary metabolite production within F. fujikuroi. Species- and lineage-specific genes, many of which appear to exhibit expression profiles that are consistent with roles in host-pathogen interactions and adaptation to environmental changes, are concentrated in subtelomeric regions. These genomic compartments also exhibit distinct gene densities and compositional characteristics with respect to other genomic partitions, and likely play a role in the generation of molecular diversity. Our data provide additional evidence that gene duplication, divergence, and differential loss play important roles in F. fujikuroi genome evolution and suggest that hundreds of lineage-specific genes might have been acquired through horizontal gene transfer.
对来自三个地理上不同的藤仓镰孢菌分离株的基因组草图序列与最近发表的同一物种的两个基因组序列进行比较，结果表明藤仓镰孢菌内次生代谢产物的产生具有不同的特征。物种特异性和谱系特异性基因集中在亚端粒区域，其中许多基因的表达谱似乎与宿主-病原体相互作用及适应环境变化的作用一致。相对于其他基因组分区，这些基因组区域也表现出不同的基因密度和组成特征，并且可能在分子多样性的产生中发挥作用。我们的数据提供了额外的证据，表明基因复制、分化和差异丢失在藤仓镰孢菌基因组进化中起重要作用，并表明数百个谱系特异性基因可能是通过水平基因转移获得的。
