Lin You-Rong, Chan Chia-Hao, Lee Hui-Ting, Cheng Sheng-Jen, Yang Jia-Wei, Chang Shing-Jyh, Lin Shien-Fong, Chen Guan-Yu
Institute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan.
Department of Electrical and Computer Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan.
Nanomaterials (Basel). 2019 Apr 4;9(4):551. doi: 10.3390/nano9040551.
Autophagy is the spontaneous degradation of intracellular proteins and organelles in response to nutrient deprivation. The phagocytosis of iron oxide nanoparticles (IONPs) results in intracellular degradation that can be exploited for use in cancer treatment. Non-invasive magnetic control has emerged as an important technology, with breakthroughs achieved in areas such as magneto-thermal therapy and drug delivery. This study aimed to regulate autophagy in mouse B-lymphoma cells (A20) through the incorporation of IONPs-quantum dots (QDs). We hypothesized that with the application of an external magnetic field after phagocytosis of IONPs-QDs, autophagy of intracellular IONPs-QDs could be regulated in a non-invasive manner and subsequently modulate the regulation of inflammatory responses. The potential of this approach as a cancer treatment method was explored. The application of IONPs and an external magnetic force enabled the non-invasive regulation of cell autophagy and modulation of the self-regulatory function of cells. The combination of non-invasive magnetic fields and nanotechnology could provide a new approach to cancer treatment.
自噬是细胞内蛋白质和细胞器在营养缺乏时的自发降解过程。氧化铁纳米颗粒（IONPs）的吞噬作用会导致细胞内降解，可用于癌症治疗。非侵入性磁控技术已成为一项重要技术，在磁热疗法和药物递送等领域取得了突破。本研究旨在通过掺入IONP-量子点（QD）来调节小鼠B淋巴瘤细胞（A20）中的自噬。我们假设在IONP-QD被吞噬后施加外部磁场，可以以非侵入性方式调节细胞内IONP-QD的自噬，进而调节炎症反应的调控。探索了这种方法作为癌症治疗方法的潜力。IONP和外部磁力的应用能够非侵入性地调节细胞自噬并调节细胞的自我调节功能。非侵入性磁场与纳米技术的结合可为癌症治疗提供一种新方法。
