Limongi Tania, Susa Francesca, Cauda Valentina
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy.
Hematol Med Oncol. 2019 Jun 28;4:1000183. doi: 10.15761/hmo.1000183.
Nanotechnology, as an interdisciplinary science, combines engineering, physics, material sciences, and chemistry with the biomedicine knowhow, trying the management of a wide range of diseases. Nanoparticle-based devices holding tumor imaging, targeting and therapy capabilities are formerly under study. Since conventional hematological therapies are sometimes defined by reduced selectivity, low therapeutic efficacy and many side effects, in this review we discuss the potential advantages of the NPs' use in alternative/combined strategies. In the introduction the basic notion of nanomedicine and nanoparticles' classification are described, while in the main text nanodiagnostics, nanotherapeutics and theranostics solutions coming out from the use of a wide-ranging NPs availability are listed and discussed.
纳米技术作为一门交叉学科,将工程学、物理学、材料科学和化学与生物医学知识相结合,致力于应对多种疾病。基于纳米颗粒的具有肿瘤成像、靶向和治疗能力的装置目前正在研究中。由于传统血液学疗法有时存在选择性降低、治疗效果低和诸多副作用的问题,在本综述中,我们讨论了纳米颗粒在替代/联合策略中应用的潜在优势。在引言部分描述了纳米医学的基本概念和纳米颗粒的分类,而在正文部分列出并讨论了由于广泛使用纳米颗粒而产生的纳米诊断、纳米治疗和诊疗一体化解决方案。