给癌细胞打上铁死亡的标签。
DUBbing Ferroptosis in Cancer Cells.
机构信息
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
出版信息
Cancer Res. 2019 Apr 15;79(8):1749-1750. doi: 10.1158/0008-5472.CAN-19-0487.
Abstract
Ferroptosis, a form of iron-dependent, nonapoptotic cell death that is induced by excessive lipid peroxidation, has been recently identified as a new tumor suppression mechanism. In this issue of , Liu and colleagues demonstrate that the deubiquitinase (DUB) OTUB1 is frequently overexpressed in human cancers, and functions to "dub" (trim) the ferroptosis process in cancer cells and promotes tumor development by stabilizing the cystine transporter, SLC7A11. This study not only reveals a hitherto unappreciated regulatory mechanism of ferroptosis but also identifies potential therapeutic targets for cancer treatment..
摘要
铁死亡是一种由脂质过氧化作用引起的铁依赖性非凋亡性细胞死亡，最近被认为是一种新的肿瘤抑制机制。在本期的《细胞》杂志中，刘博士及其同事证明去泛素化酶（DUB）OTUB1 在人类癌症中经常过表达，并通过稳定胱氨酸转运蛋白 SLC7A11 来“泛素化”（修剪）癌细胞中的铁死亡过程，从而发挥作用，促进肿瘤的发展。这项研究不仅揭示了铁死亡调控机制的一个新的未知方面，还为癌症治疗确定了潜在的治疗靶点。
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本文引用的文献
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The Deubiquitylase OTUB1 Mediates Ferroptosis via Stabilization of SLC7A11.去泛素化酶 OTUB1 通过稳定 SLC7A11 介导线粒体铁死亡。
Cancer Res. 2019 Apr 15;79(8):1913-1924. doi: 10.1158/0008-5472.CAN-18-3037. Epub 2019 Feb 1.
2
Role of GPX4 in ferroptosis and its pharmacological implication.谷胱甘肽过氧化物酶 4 在铁死亡中的作用及其药理学意义。
Free Radic Biol Med. 2019 Mar;133:144-152. doi: 10.1016/j.freeradbiomed.2018.09.014. Epub 2018 Sep 13.
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BAP1 links metabolic regulation of ferroptosis to tumour suppression.BAP1 将铁死亡代谢调控与肿瘤抑制联系起来。
Nat Cell Biol. 2018 Oct;20(10):1181-1192. doi: 10.1038/s41556-018-0178-0. Epub 2018 Sep 10.
4
Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer.氨基酸转运蛋白 SLC7A11/xCT 在调节氧化还原平衡和肿瘤营养依赖性的十字路口。
Cancer Commun (Lond). 2018 Apr 25;38(1):12. doi: 10.1186/s40880-018-0288-x.
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NRF2 and the Hallmarks of Cancer.NRF2 与癌症的特征。
Cancer Cell. 2018 Jul 9;34(1):21-43. doi: 10.1016/j.ccell.2018.03.022. Epub 2018 May 3.
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Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins.由两种不同蛋白质组成的质膜胱氨酸/谷氨酸交换转运体的克隆与表达。
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